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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2009年第6期

页码:

838-840

栏目:

临床研究

出版日期:

2009-11-05

文章信息/Info

Title:

Effect of bisoprolol on left ventricular hypertrophy

作者:

张博

锦州市中心医院心内科,辽宁 锦州 121000

Author(s):

ZHANG Bo

Department of Cardiology, Jinzhou Central Hospital, Jinzhou 121000, Liaoning, China

关键词:

高血压; 原发性; 比索洛尔; 左室重构

Keywords:

hypertension;  bisoprolol;  ventricular remodeling

分类号:

R544.1

DOI:

-

文献标识码:

A

摘要:

目的: 探讨比索洛尔对原发性高血压病左室肥厚的逆转作用。方法: 选择40例轻中度高血压病伴左室肥厚患者，口服比索洛尔24周，测量服药前后血压变化；通过超声心动图测量患者服药前后舒张末期室间隔厚度（LVST），舒张末期左室后壁厚度（LVPWT），左室舒张末内径（LVEDD），左心室质量指数（LVMI）。检测服药前后血清中Ⅲ型前胶原（PCⅢ），胰岛素样生长因子（IGF-I），肿瘤坏死因子-α（TNF-α）的变化。结果: 治疗后上述指标较治疗前明显减低，差异有显著性（P<0.01）。结论: 比索洛尔能有效降低血压并逆转左室肥厚，其机制可能与抑制IGF-I、TNF-α的生成有关。

Abstract:

AIM: To observe the effect of bisoprolol on left ventricular hypertrophy. METHODS: Forty patients with essential hypertension and left ventricular hypertrophy (LVH) were treated with bisoprolol (2.5-10 mg/day) for 24 weeks. Blood pressure, left ventricle diastolic dimension (LVEDD), interventricular septum thickness (LVST), left ventricle mass index (LVMI), left ventricle posterior wall thickness (LVPWT), procollagen type III (PCIII), insulin-like growth factor-I (IGF-I), and tumor necrosis factor-α (TNF-α) were measured before and after treatment. RESULTS: After bisoprolol treatment, blood pressure and LVMI, LVPWT, LVST and LVEDD levels significantly decreased (P<0.01). In addition, PCIII, IGF-I and TNF-α levels also significantly decreased (P<0.01). CONCLUSION: Bisoprolol lowers hypertension and reverses LVH. The protective mechanism may be related to its ability to reduce IGF-I and TNF-α.

参考文献/References

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［6］ 于学军,何作云,戚文航,等. 心肌组织内IGF-I和TGF-β1在高血压不同发病阶段的表达及意义［J］. 第三军医大学学报, 2001, 23(4):410-412.

［7］ 潘丽丽,王瑞英,朱国斌. 胰岛素样生长因子-I与高血压左心室肥厚的相关性［J］. 中国药物与临床, 2007, 7(2):103-105.

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备注/Memo

备注/Memo:

收稿日期：2008-11-3.作者简介：张博，主治医师，硕士Email:zhangbo5813@163.com

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更新日期/Last Update: 2009-09-30