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|本期目录/Table of Contents|

肝细胞生长因子对急性心肌梗死后左室重构的预测作用

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第2期
页码:
222-224
栏目:
临床研究
出版日期:
2010-03-04

文章信息/Info

Title:
Serum hepatocyte growth factor in predicting left ventricular remodeling after acute myocardial infarction
作者:
张莉1; 刘丰2
1.增城市人民医院心内科，广东 广州 511300；2.广州市第一人民医院老年科，广东 广州 510180
Author(s):
ZHANG Li1;  LIU Feng2
1.Department of Cardiology, Zengcheng People’s Hospital, Guangzhou 511300, Guangdong, China; 2.Department of Geriatrics, Guangzhou First Municipal Hospital, Guangzhou 510180, Guangdong, China
关键词:
心肌梗死; 急性; 肝细胞生长因子; 左室重构
Keywords:
acute myocardial infarction;  hepatocyte growth factor;  left ventricular remodeling
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的: 探讨血清肝细胞生成因子(HGF)对急性心肌梗死(AMI)后早期左室重构的预测价值。方法: 36例AMI患者入院时及发病7 d测定血清HGF水平；AMI其中的26例分别于发病后7~10 d及发病后3个月行超声心动图检查，3个月时左室舒张末期容积指数（LVEDVI）与7~10 d时比增加≥5 ml/m2定义为左室重构组(n=11)，对两组血清HGF值进行比较。结果: AMI患者入院时血清HGF浓度较对照组明显升高［(809±288)ng/L vs.(620±162)ng/L，P<0.01］，7 d时升高更显著［(1 607±1 355)ng/L，P<0.01］。发病7 d时血清HGF浓度在左室重构组较非左室重构组升高［(2 216±1 522)ng/L vs.(1 176±593)ng/L，P<0.05］，而入院时两组浓度则无显著差异。结论: AMI时血清HGF浓度升高，AMI后7 d时增高的血清HGF可能预示心室重构。
Abstract:
AIM: To investigate the clinical significance of serum hepatocyte growth factor (HGF) in predicting left ventricular remodeling after acute myocardial infarction (AMI). METHODS: Venous blood samples were obtained at hospital admission and 7 days after in 36 patients with AMI and in 27 control subjects. Left ventricular end-diastolic volume index (LVEDVI) in the subacute (7-10 days) and chronic (3 months) phases was assessed in 26 patients with AMI. Left ventricular remodeling group (n=11) was defined as an increase in LVEDVI 5 ml/m2 in chronic phase relative to the subacute phase. RESULTS: Serum HGF concentrations were higher in newly admitted patients with AMI than those in controls ［(809±288) vs.(620±162) ng/L, P<0.01］ and the difference was more significant on day 7 (1 607±1 355 ng/L) than at admission (P<0.01). HGF concentration on day 7 was higher in the remodeling group than in the nonremodeling group ［(2216±1522） vs.(1176±593) ng/L, P<0.05］, whereas no difference was observed between the groups at admission. CONCLUSION: Serum HGF concentration is elevated in patients with AMI. Elevated serum HGF concentrations on day 7 after AMI may forebode left ventricular remodeling.

参考文献/References

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［3］ Strain AJ, McGowan JA. Stimulation of DNA synthesis in primary cultures of adult rat hepatocytes by platelet-associated substance(s)［J］. In Vitro, 1982, 18(2):108-116.

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备注/Memo

备注/Memo:
收稿日期：2008-12-31.作者简介：张莉，主治医师，博士生Email:zhangli4029@yahoo.com.cn
更新日期/Last Update: 2010-03-05