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|本期目录/Table of Contents|

载脂蛋白AV研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第2期
页码:
273-275
栏目:
综述
出版日期:
2010-03-04

文章信息/Info

Title:
-
作者:
何成毓; 李洁琪; 卜婕
贵阳医学院附属医院心内科，贵州 贵阳 550044
Author(s):
-
关键词:
载脂蛋白; 血脂代谢; 基因多态性
Keywords:
-
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
载脂蛋白AV(ApoAV)是2001年两个独立研究小组用不同的方法同时发现的一个新的血浆载脂蛋白家族成员。本文就ApoAV对脂代谢影响的作用机制及ApoAV基因多态性与冠心病的关系作一综述。
Abstract:
-

参考文献/References

［1］ Genoux A, Dehondt H, Helleboid-Chapman A, et al. Transcriptional regulation of apolipoprotein A5 gene expression by the nuclear receptor RORalpha［J］. Arterioscler Thromb Vasc Biol, 2005, 25(6):1186-1192.

［2］ Prieur X, Huby T, Coste H, et al. Thyroid hormone regulates the hypotriglyceridemic gene APOA5［J］. J Biol Chem, 2005, 280(30):27533-27543.

［3］ Nowak M, Helleboid-Chapman A, Jakel H, et al. Insulin-mediated down-regulation of apolipoprotein A5 gene expression through the phosphatidylinositol 3-kinase pathway: role of upstream stimulatory factor［J］. Mol Cell Biol, 2005, 25(4):1537-1548.

［4］ O’Brien PJ, AlbornWE, Sloan JH, et al. The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins［J］. Clin Chem, 2005, 51(2):351-359.

［5］ Ishihara M, Kujiraoka T, Iwasaki T, et al. A sandwich enzyme-linked immunosorbent assay for human plasma apolipoprotein A-V concentration［J］. J Lipid Res, 2005, 46(9):2015-2022.

［6］ 刘琼，赵水平. 人载脂蛋白AV多克隆抗体的制备和组织分布［J］. 中国实用内科杂志, 2006, 26（16）：1275-1278.

［7］ 胡松，赵水平，刘琼，等. 人血清载脂蛋白AV的检测及与血脂的相关性［J］. 中国动脉硬化杂志, 2007, 15(2):145-147.

［8］ Rensen PC, van Dijk KW, Havekes LM. Apolipoprotein AV: low concentration, high impact［J］. Arterioscler Thromb Vasc Biol, 2005, 25(12):2445-2447.

［9］ Olofsson SO. ApoA-V: the regulation of a regulator of plasma triglycerides［J］. Arterioscler Thromb Vasc Biol, 2005, 25(6):1097-1099.

［10］Merkel M, Loeffler B, Kluger M, et al. Apolipoprotein AV acceleratesplasma hydrolysis of triglyceride-rich lipoproteins by interaction withproteoglycan－bound lipoprotein lipase［J］. J Biol Chem, 2005, 280(22):21553-21560.

［11］Loredan SN, Jamila FN, Jean-Charles F, et al. Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome［J］. Clin Chem Lab Med, 2007, 45(9):1133-1139.

［12］Oliva CP, Pisciotta L, LiVolti G, et al. Inherited apolipoprotein A-V deficiency in severe hypertriglyceridemia［J］. Arterioscler Thromb Vasc Biol, 2005, 25(2):411-417.

［13］Dorfmeister B, Zeng WW, Dichlberger A, et al. Effects of Six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding［J］. Arterioscler Thromb Vasc Biol, 2008, 28(10):1866-1871.

［14］Tang Y, Sun P, Guo D, et al. A genetic variant c. 553G>T in the apolipoprotein A5 gene is associated with an increased risk of coronary artery disease and altered triglyceride levels in a Chinese population［J］. Atherosclerosis, 2006, 185(2):433-437.

［15］Dallongeville J, Cottel D, Montaye M, et al. Impact of APOA5/A4/C3 genetic polymorphisms on lipid variables and cardiovascular disease risk in French men［J］. Int J Cardiol, 2006, 106(2):152-156.

［16］桑震池，陈书艳. 他汀类药物、烟酸、抗氧化剂对降脂和冠状动脉粥样硬化的作用［J］ . 心脏杂志, 2008, 20(4):487-490.

备注/Memo

备注/Memo:
收稿日期：2008-12-24.通讯作者：李洁琪，副主任医师，主要从事血脂与冠心病的研究Email:jieqili2003@yahoo.com.cn 作者简介：何成毓，主治医师，硕士Email:hcyu1020@sina.com
更新日期/Last Update: 2010-03-05