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|本期目录/Table of Contents|

尼莫地平和灯盏花改善心肌细胞抗损伤的实验研究

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第4期
页码:
510-513
栏目:
基础研究
出版日期:
2010-06-10

文章信息/Info

Title:
Protective effect of nimodipine and erigeron breviscapus on alcohol-induced myocardial injury
作者:
时静华; 潘桂兰; 陈晓东
包头医学院生理学教研室，内蒙古 包头 014010
Author(s):
SHI Jing-hua;  PAN Gui-lan;  CHEN Xiao-dong
Department of Physiology, Baotou Medical College, Baotou 014010, Neimenggu, China
关键词:
乙醇; 心肌损伤; 尼莫地平; 灯盏花; 大鼠
Keywords:
alcohol;  myocardial injury;  nimodipine;  breviscapus
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
目的: 探讨尼莫地平和灯盏花改善饮酒致心功能损伤的作用。方法: 将72只Wistar大鼠随机分为A~F6个组，每组12只大鼠，即A：对照组，B：1.5 ml饮用酒组，C：1.0 ml饮用酒组，D：1.25 mg尼莫地平干预组，E：1.25 mg灯盏花组，F：尼莫地平+灯盏花组（简称1.25 mg联合组）。分别于经胃灌酒前、后，经眶静脉丛采血分离血清，酶联免疫法检测血清肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白Ⅰ(cTnI)；比色法检测丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)含量的变化。于灌酒后第14天，取心肌组织检测组织匀浆中MDA和GSH-Px含量的变化。结果: D、E、F3组血清CK-MB、cTnI和MDA的含量均明显低于A、B两组（P<0.05）；而GSH-Px的含量比A、B组升高。D、E、F组心肌组织匀浆中MDA的含量明显低于A、B两组（P<0.01）。结论: 尼莫地平和灯盏花可改善饮酒所致心功能的损伤。
Abstract:
AIM: To investigate the protective effect of nimodipine and breviscapus on alcohol-induced myocardial injury. METHODS: Seventy-two Wistar rats were randomly divided according to the alcohol dose and protective medicine administered. Blood was collected dynamically before and after alcohol administration to detect CK-MB, cTnI, MDA and GSH-Px in serum, and myocardium tissue was obtained 14 days after alcohol administration to examine the content changes of MDA and GSH-Px in myocardium homogenate. RESULTS: Contents of CK-MB, cTnI and MDA in each subgroups of protective medicine were lower than those in alcohol-administered subgroups, and GSH-Px increased significantly (P<0.05). In subgroups of protective medicine, MDA content in myocardium homogenate was lower than in alcohol-administered subgroups (P<0.01). CONCLUSIONS: Nimodipine and breviscapus exert some protective effect on alcohol-induced myocardial injury.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2009-06-01.通讯作者：潘桂兰，教授，主要从事心血管生理研究 Email:pgl7626@sina.com 作者简介：时静华，讲师，硕士Email:jinghuas@126.com
更新日期/Last Update: 2010-05-20