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|本期目录/Table of Contents|

冠心病患者血清缺氧诱导因子-1α与血管内皮生长因子水平的变化

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第4期
页码:
554-555,559
栏目:
临床研究
出版日期:
2010-06-10

文章信息/Info

Title:
Changes of serum hypoxia-inducible factor-1α and vascular endothelial growth factor in patients with coronary heart disease
作者:
马晓艳1; 张言镇2; 周衍菊2
1.潍坊医学院内科学教研室，山东 潍坊 261041；2.潍坊市人民医院急诊科，山东 潍坊 261041
Author(s):
MA Xiao-yan1;  ZHANG Yan-zhen2;  ZHOU Yan-ju2
1.Department of Internal Medicine, Weifang Medical College, Weifang 261041, Shandong, China; 2.Department of Emergency, Weifang People’s Hospital, Weifang 261041, Shandong, China
关键词:
血管内皮生长因子; 低氧诱导因子-1α; 管状动脉疾病; 急性冠脉综合征
Keywords:
vascular endothelial growth factor;  hypoxia-inducible factor-1α;  coronary diseases;  acute coronary syndrome
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的: 研究冠心病(CHD)患者血清血管内皮生长因子（vascular endothelial growth factor，VEGF）和低氧诱导因子-1α（hypoxia inducible factor 1α,HIF-1α）水平的变化意义。方法: CHD患者79例，分为急性冠脉综合征(ACS)组42例，稳定型心绞痛（SAP）组37例，另选35例作为对照组，所有患者清晨空腹抽血应用ELISA法测定VEGF和HIF-1α水平。结果: ACS组VEGF和HIF-1α水平显著高于SAP组和对照组(P<0.05);SAP组VEGF和HIF-1α水平与对照组比较差异无统计学意义。结论: VEGF和HIF-1α水平升高可能是冠状动脉粥样硬化斑块的不稳定的标志。
Abstract:
AIM: To study the serum level of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α) in patients with coronary heart disease (CHD) and to discuss their clinical significance. METHODS: Seventy-nine patients with CHD were chosen and divided into two group: acute coronary syndrome (ACS) group (n=42) and stable angina pectoris (SAP) group (n=37). Thirty-five healthy subjects were chosen as control group. Serum levels of VEGF and HIF-1α from fasting blood were tested in all patients using ELISA. RESULTS: Serum levels of VEGF and HIF-1α in ACS group were higher than those in SAP group and control group (P<0.05). No difference was observed in VEGF and HIF-1α between SAP and control group. CONCLUSION: Elevated levels of VEGF and HIF-1α may be signs of atherosclerotic plaque destabilization.

参考文献/References

［1］陈治，黄宗海. 缺氧诱导因子-1的研究与应用进展［J］. 国外医学·生理、 病理科学与临床分册, 2004, 24（1）:34-37.

［2］郝亚荣,李建军,江洪,等. 冠心病患者血清VEGF水平的研究［J］. 心脏杂志, 2004, 16(4):339-341.

［3］Chen F, Erilksson P, Herzfeld I, et al. Apoptosis and angiogenesis are induced in the unstable coronary atherosclerotic plaque［J］. Coron Artery Dis, 2005, 16(3):191-197.

［4］王长谦,汤大鸣,王利民,等. VEGF对人血单核细胞基质金属蛋白酶表达及活性的影响［J］. 心脏杂志, 2004, 16(4):308-311.

［5］Rodriguze JA, Nespereira B, Perez-llzarbe M, et al. Vitamins C and E prevent endothelial VEGF and VEGFR-2 overexpreession induced by procine hypercholesterolemic LDL［J］. Cardiovasc Res, 2005, 65(3):665-673.

［6］孙璐,韦立新,石怀银,等. 冠状动脉粥样硬化斑块内血管新生与斑块稳定性的关系［J］. 中华病理学杂志, 2003, 32(5):427-431.

［7］Hellwig-Burgel T, Stiehl DP, Wagner AE, et al. Hypoxia-inducible factor-1(HIF-1):A novel transcription factor in immune reactions［J］. Interferon Cytokine Res, 2005, 25(6):297-310.

[8]Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system［J］. Nat Med, 2003, 9(6):677-684.

[9]Sluimer JC, Gasc JM, van Wanroij JL, et al. Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis［J］. J Am Coll Cardial, 2008, 51(13):1258-1265.

［10］Tal R, Shaish A, Bangio L, et al. Activation of C-transactivation domain is essential for optimal HIF-1alpha-mediated transcriptional and angiogenic effect［J］. Microvasc Res, 2008, 76(1):1-6.

备注/Memo

备注/Memo:
收稿日期：2008-09-19.通讯作者：张言镇，主任医师，主要从事急诊心脏介入研究 Email:zhangyanzhenjz@163.com 作者简介：马晓艳,硕士生Email:maxiaoyan303@126.com
更新日期/Last Update: 2010-05-20