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|本期目录/Table of Contents|

国产与进口药物洗脱支架治疗前降支开口病变的临床疗效比较

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第4期
页码:
556-559
栏目:
临床研究
出版日期:
2010-06-10

文章信息/Info

Title:
Comparison of the efficacy between Chinese-made and USA-made drug-eluting stents in treatment of ostial lesions of the left anterior descending coronary artery
作者:
李东宝; 华琦; 刘志; 李静; 许立庆; 王珊; 金尉英
首都医科大学宣武医院心脏科，北京 100053
Author(s):
LI Dong-bao;  HUA Qi;  LIU Zhi;  LI Jing;  XU Li-qing;  WANG Shan;  JIN Wei-ying
Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
关键词:
药物洗脱支架; 左前降支开口病变; 经皮冠状动脉脉介入治疗
Keywords:
sirolimus-eluting stent;  left anterior descending coronary artery ostial lesion;  percutaneous coronary intervention
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的: 比较国产与进口药物洗脱支架治疗前降支开口病变的临床疗效。方法: 回顾性分析95例前降支开口病变的患者置入国产支架（国产支架组，n=68）和进口支架（进口支架组，n=27），所有患者均行临床随访，部分患者进行了冠状动脉造影（CAG）复查。结果: 国产支架组的急性心肌梗死患者多于进口支架组，但无统计学差异（46% vs. 33%）。两组的介入成功率均为100%。国产支架组的冠脉钙化率、偏心斑块率和C型病变率均高于进口支架组（分别为20% vs. 4%；14% vs. 0%；28% vs. 7%，均P<0.05）。两组CAG随访的支架内和血管段再狭窄率无统计学差异；两组的主要不良事件发生率也无统计学差异。结论: 国产药物洗脱支架治疗前降支开口病变是安全的，与进口药物洗脱支架具有相似的良好疗效。
Abstract:
AIM: To compare the efficacy of Chinese-made and USA-made sirolimus-eluting stents in the treatment of ostial lesion of the left anterior descending (LAD) coronary artery. METHODS: Ninety-five patients with LAD ostial lesion were implanted with stents made in China (Chinese-made stent group, n=68) or stents made in the USA (USA-made stent group, n=27). Follow-ups were conducted in all patients and angiographic examinations were performed in some patients. RESULTS: The procedure was successful in all patients. More acute myocardial infarction was observed in Chinese-made stent group but no significant difference was found between groups (46% vs. 33%, P=0.31). Significantly more calcified, eccentric plaques and C-type lesions were seen in the Chinese-made stent group compared with those seen in the USA-made stent group (20% vs. 4%; 14% vs. 0%; 28% vs. 7%, P<0.05), but angiographic follow-up showed no significant difference in the rate of in-stent and in-segment restenosis between groups. No significance was observed in the rate of main adverse events between groups. CONCLUSION: Compared with USA-made sirolimus-eluting stents, Chinese-made sirolimus-eluting stents are as safe and effective in the treatment of LAD coronary artery ostial lesion.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2009-03-28.通讯作者：华琦，教授，主要从事高血压病、冠心病的研究 Email:huaqi5371@medmail.com.cn 作者简介：李东宝，副主任医师Email:leetobo@sina.com
更新日期/Last Update: 2010-05-20