我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

血清C反应蛋白在评价冠心病并发糖尿病严重程度的临床应用

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第5期
页码:
739-741
栏目:
临床研究
出版日期:
2010-06-22

文章信息/Info

Title:
Clinical significance of plasma C-reactive protein levels in patients with diabetes mellitus complicated with coronary heart disease
作者:
陈韬; 汪沁沁; 梁春; 任雨笙; 吴宗贵
第二军医大学附属长征医院心内科，上海 200003
Author(s):
CHEN Tao;  WANG Qin-qin;  LIANG Chun;  REN Yu-sheng;  WU Zong-gui
Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China
关键词:
C反应蛋白; 糖尿病; 冠状动脉疾病; Gensini评分
Keywords:
C-reactive protein;  diabetes mellitus;  coronary disease;  Gensini score
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的: 探讨血浆C反应蛋白（CRP）水平的变化对冠心病并发Ⅱ型糖尿病（DM）患者的临床意义。方法： 经冠脉造影诊断的冠心病患者61例，按有无并发糖尿病分为并发糖尿病组（30例），单纯冠心病组（31例），所有研究对象测定空腹静脉血、CRP、空腹血糖（FBG）、糖化血红蛋白（HbA1c）、血脂等指标，并结合冠脉造影结果计算Gensini评分，将各指标进行组间比较，并进行多元回归分析。结果： 并发糖尿病组血CRP、FBG、HbA1c均显著高于单纯冠心病组（P<0.01）；并发糖尿病组患者的冠脉病变Gensini评分和三支病变者明显多于单纯冠心病组患者（P<0.05）；经线性回归分析显示，冠状动脉病变严重程度与CRP、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL- C）、低密度脂蛋白胆固醇（LDL-C）、体质量指数（BMI）显著相关（均P<0.01）。结论： 冠心病患者并发Ⅱ型糖尿病将加重冠状动脉病变严重程度，糖尿病患者血清CRP水平升高不仅是糖尿病并发冠心病的重要危险因子，也是反映糖尿病冠状动脉广泛弥漫和严重病变的重要指标。
Abstract:
AIM：To investigate the relationship between elevated plasma C-reactive protein (CRP) levels and coronary heart disease (CHD) in patients with type II diabetes mellitus (T2DM). METHODS: Sixty-one patients with CHD diagnosed by coronary angiography were divided into two groups: 30 cases with T2DM in group A and 31 cases without T2DM in group B, and 30 healthy subjects were assigned to group C as control. The levels of plasma CRP, fasting blood glucose (FBG), blood lipids and BMI were detected and compared between groups. RESULTS: Significant differences were found in the levels of CRP, FBG and HbA1c among the three groups. Gensini score and percentage of three-branch lesions in patients with T2DM were higher than those in patients without T2DM (P<0.01). Simple correlation analysis indicated that severity of coronary artery disease (CAD) was significantly correlated with CRP, TG, TC, HDL-C, LDL-C and body mass index (P<0.01). CONCLUSION: The coronary lesions of CHD patients with T2DM tend to be more widespread and more severe. Increased serum CRP level is an important risk factor for T2DM complicated with CAD and a vital parameter for diffuse CAD in patients with T2DM.

参考文献/References

［1］倪长霖，张亚文，胡筱芸． 2型糖尿病合并冠心病危险因素的临床研究［J］． 天津医药， 2006， 34(9)：607-609．

［2］Gensini GG. A more meaningful scoring system for determining the serverity of coronary heart disease ［J］. Am J Cardiol, 1983, 51(3):606.

［3］ Burke AP, Kolodgie FD, Zieske A, et al. Morphologic findings of coronary atherosclerotic plaques in diabetics: a postmortem study ［J］. Arterioscler Thromb Vasc Biol, 2004, 24(7):1266-1271．

［4］Takaishi H, Taniguchi T, Fujioka Y, et al. Impact of increasing diabetes on coronary artery disease in the past decade［J］. J Atheroscler Thromb, 2004, 11(5):271-277．

［5］Shankar A, Li J, Nieto FJ, et al. Association between C-reactive protein level and peripheral arterial disease among US adults without cardiovascular disease, diabetes, or hypertension［J］. Am Heart J, 2007, 154(3)：495-501．

［6］ Barzilay JI, Abraham L, Heckbert SR, et al. The relation of markers of inflammation to the development of glucose disorders in the elderly: the Cardiovascular Health Study［J］. Diabetes, 2001, 50(10)：2384-2389．

［7］韩红彦，万为国，王燕，等． 冠心病合并糖尿病患者C反应蛋白和尿酸变化及意义［J］． 疑难病杂志， 2006， 5(6)：420-421．

备注/Memo

备注/Memo:
收稿日期：2010-01-10.通讯作者：任雨笙，副教授，主要从事动脉粥样硬化性心脏病防治研究Email:renyusheng@hotmail.com 作者简介：陈韬，硕士生Email:ilion31@163.com
更新日期/Last Update: 2010-06-22