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应用血管内超声显像技术评价高敏性C反应蛋白与不稳定型心绞痛的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第5期
页码:
742-743，746
栏目:
临床研究
出版日期:
2010-06-22

文章信息/Info

Title:
Intravascular ultrasound evaluation of high-sensitivity C-reactive protein in unstable angina patients
作者:
贾如意; 虞华鹏; 赵成军; 王涛; 浦艳华
济南市第四人民医院心内科，济南市心血管病研究所，山东 济南 250031
Author(s):
JIA Ru-yi;  YU Hua-peng;  ZHAO Cheng-jun;  WANG Tao;  PU Yan-hua
Jinan Institute of Cardiovascular Disease, Department of Cardiology, Jinan Fourth People’s Hospital, Jinan 250031, Shandong, China
关键词:
血管内超声; 心绞痛; 不稳定型; C反应蛋白; 动脉粥样硬化
Keywords:
intravascular ultrasound;  unstable angina;  C-reactive protein;  atherosclerosis
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的: 应用血管内超声（intravascular ultrasound，IVUS）技术探讨血清高敏性C反应蛋白（hsCRP）与冠心病不稳定型心绞痛（UAP）的关系。方法: 38例拟诊为冠心病患者行冠状动脉造影（coronary angiography，CAG）和IVUS检查，其中8例患者经CAG和IVUS检查未发现冠脉有明显病变为对照组；30例经IVUS检查发现冠脉有明显狭窄病变，为冠心病组，其中UAP 18例、稳定型心绞痛（SAP）12例。检测所有患者的hsCRP浓度。结果: 38例患者均有不同程度的内膜增厚；8例对照组无动脉粥样硬化(AS)斑块；30例冠心病患者IVUS示有不同类型的AS斑块。UAP组患者血清hsCRP水平显著高于SAP组及对照组；不稳定斑块组hsCRP水平高于稳定斑块组。结论: UAP患者血清hsCRP水平明显增高，提示hsCRP水平升高与AS斑块不稳定有关。
Abstract:
AIM: To evaluate high-sensitivity C-reactive protein (hsCRP) in unstable angina patients using intravascular ultrasound (IVUS). METHODS: Thirty-eight patients suspected of having coronary heart disease (CHD) underwent coronary angiography and IVUS examinations. Eight patients without significant coronary artery stenosis were assigned to the control group and 30 patients with significant coronary artery stenosis were assigned to the CHD group including unstable angina pectoris (UAP, 18 cases) and stable angina group (SAP, 12 cases). Serum hsCRP concentrations were detected in all patients. RESULTS: Endothelial thickening of varying degrees was observed in all 38 patients. IVUS showed atherosclerotic plaques of different types in the 30 patients in the CHD group but no atherosclerotic plaques in the control group. hsCRP in UAP cases was significantly higher than in SAP patients and in control group. Levels of hsCRP in unstable plaques were higher than those in stable plaques. CONCLUSION: Serum hsCRP is significantly higher in patients with UAP, indicating that increasing levels of hsCRP are correlated with unstable plaques of UAP patients.

参考文献/References

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［2］ Stenvinkel P. C-reactive protein-does it promote vascular disease?［J］. Nephrol Dial Transplant, 2006, 21(10):2718-2720.

［3］叶任高，陆再英. 内科学［M］. 第6版. 北京:人民卫生出版社, 2004:278.

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［5］Paul A, Ko KW, Li L, et al. C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice［J］. Circulation, 2004, 109(5):647-655.

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备注/Memo

备注/Memo:
收稿日期：2009-05-29.基金项目：济南市卫生局科研基金资助（济卫科外发［2006］34号） 作者简介：贾如意，主任医师，博士，主要从事冠心病临床和基础研究Email：jrycardiology@sohu.com
更新日期/Last Update: 2010-06-22