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急性左心衰竭患者无创正压通气对血浆高敏肌钙蛋白T水平的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2011年第6期
页码:
775-778
栏目:
临床研究
出版日期:
2011-12-25

文章信息/Info

Title:
Effects of noninvasive positive pressure ventilation on plasma hs-troponin T changes in patients with acute left ventricular failure
作者:
刘 东; 李定武; 张智喜
同济医学院附属东莞医院心内科，广东 东莞 523416
Author(s):
LIU Dong;  LI Ding-wu;  ZHANG Zhi-xi
Department of Cardiology, Dongguan Affiliated Hospital, Tongji Medical College, Dongguan 523416, Guangdong, China
关键词:
无创正压通气; 急性左心衰竭; 高敏肌钙蛋白T
Keywords:
positive pressure ventilation;  acute left ventricular failure;  hs troponin T
分类号:
R541.61
DOI:
-
文献标识码:
A
摘要:
目的:观察无创正压机械通气(NIPPV)对急性左心衰竭血浆高敏肌钙蛋白T（hs-TnT）水平的影响。方法： 选择急性左心衰竭患者46例随机分为2组，NIPPV组26例，常规治疗组20例，两组都在常规药物治疗基础上，常规治疗组给予高流量面罩吸氧，NIPPV组则经面罩双水平NIPPV给氧,观察2组病例治疗前后的临床疗效以及血浆hs-TnT水平。结果： NIPPV组临床效果明显高于常规治疗组(P<0.05)。NIPPV组PaO2、SpO2、 HR、R、LVEF等改善明显高于常规治疗组(P<0.05)。治疗后24 h两组hs-TnT水平均较治疗前显著下降(P<0.05,P<0.01),NIPPV组随着时间的延长而下降(P<0.05)治疗24 h后下降更加显著(P<0.01)。结论： NIPPV能够提高急性左心衰竭的治疗效果，并能进一步降低血浆hs-TnT水平。
Abstract:
AIM:To assess the effect of noninvasive positive pressure ventilation (NIPPV) on the concentration of plasma hs-troponin T (hs-TnT) in patients with acute left ventricular failure. METHODS: A total of 46 patients with acute left ventricular failure were randomly divided into two groups: NIPPV group (n=26) and conventional treatment group (n=20). The conventional treatment group was given routine therapy and oxygen uptake, whereas the NIPPV group was given routine therapy and NIPPV. Plasma hs-TnT was measured before and after therapy in both groups. RESULTS: Better clinical effects were observed in the NIPPV group with significant differences between groups (P<0.05). PaO2, SpO2, HR, R, and LVEF in the NIPPV improved significantly higher than other conventional treatment groups (P<0.05). After 24 h therapy, hs-TnT decreased significantly in both groups (P<0.05, P<0.01) and hs-TnT in the NIPPV group was significantly lower than that in conventional group (P<0.01). CONCLUSION: NIPPV enhances the therapeutic effects and decreases plasma hs-TnT level in patients with acute left ventricular failure.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2011-02-18.作者简介：刘东，主治医师，硕士Email: lanzhould@yahoo.com.cn
更新日期/Last Update: 2011-12-27