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骨髓间充质干细胞移植治疗心肌梗死的研究进展(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第1期
页码:
117-119,137
栏目:
综述
出版日期:
2012-02-25

文章信息/Info

Title:
Progress in treatment of myocardial infarction with transplantation of bone marrow mesenchymal stem cells
作者:
田 涛 综述马 宾 审校
(蚌埠医学院第一附属医院心内科,安徽 蚌埠 233004)
Author(s):
TIAN Tao MA Bin
(Department of Angiocardiology, First Affiliated Hospital, Bengbu Medical College, Bengbu 233004. Anhui, China)
关键词:
骨髓间充质干细胞心肌梗死心肌再生
Keywords:
Bone marrow mesenchymal stem cells myocardial infarction myocardial regeneration
分类号:
R542.22
DOI:
-
文献标识码:
A
摘要:
溶栓、经皮冠状动脉介入治疗及常规药物治疗可挽救许多急性心肌梗死患者的生命,但不能从根本上恢复心肌细胞数量。骨髓间充质干细胞(BM-MSCS)是骨髓中一种具有多向分化潜能的细胞,可被诱导分化为心肌样细胞,改善梗死区的血液供应及心肌重构,为心肌梗死的治疗带来了新的希望。本文就BM-MSCS移植治疗心肌梗死的方式,移植的时机及临床应用等方面作一综述。
Abstract:
Although many patients with acute myocardial infarction can be saved by treatment of thrombolysis, percutaneous coronary intervention and conventional drugs, these approaches cannot restore the number of myocardial cells. Bone marrow mesenchymal stem cells (BM-MSCS) with their multidirectional differentiation potentials can be induced to differentiate into cardiomyocyte-like cells, improve circulation in the infarct area and prevent myocardium from remodeling. The manner, timing and clinic application of BM-MSCS transplantation for myocardial infarction are reviewed.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期:2011-07-05.通讯作者:马宾,主任医师,主要从事冠心病的研究 Email:mabin1965@163.com 作者简介:田涛,硕士生 Email:tiantaomaster@163.com
更新日期/Last Update: 2012-02-14