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|本期目录/Table of Contents|

Wnt信号通路在心肌肥厚中作用的研究进展(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第3期
页码:
411-415
栏目:
综述
出版日期:
2012-06-25

文章信息/Info

Title:
Wnt signaling pathway in myocardial hypertrophy: research progress
作者:
丁学亮; 朱烨静 综述; 尹新华 审校
(哈尔滨医科大学附属第一医院心内科，黑龙江 哈尔滨 150001)
Author(s):
DING Xue-liang;  ZHU Ye-jing;  YIN Xin-hua
(Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China)
关键词:
Wnt信号通路; 心肌肥厚; 靶点治疗
Keywords:
Wnt pathway;  myocardial hypertrophy;  target therapy
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
Wnt信号通路在细胞分化、胚胎发育、肿瘤发生及血管的形成等方面均发挥重要作用。近年来研究发现，在不同水平干预Wnt信号通路可影响心肌肥厚的发生，本文主要阐述Wnt信号通路与心肌肥厚之间相互关系的研究进展，探讨可能抑制心肌肥厚的新靶点。
Abstract:
Wnt signaling plays a key role in cell differentiation, embryonic development, tumorigenesis and angiogenesis. Recent studies have found that genetic interventions in Wnt signaling at different levels resulted in an attenuated hypertrophic response. Inhibiting Wnt signaling may thus serve as a novel therapeutic approach for cardiac hypertrophy. We reviewed the research findings on the relationship between Wnt signaling and cardiac hypertrophy and discussed the promising target for anti-hypertrophic therapy.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2011-11-23.通讯作者：尹新华，教授，主要从事冠心病和心衰研究 Email：harbin0910@yahoo.com 作者简介：丁学亮，硕士生 Email：wwwjimtom@126.com
更新日期/Last Update: 2012-05-02