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Title:: Mechanism of dysfunctional high-density lipoprotein-induced atherosclerosis

作者:: 张月¹; 马小川¹; 张涛¹; 姚亮²; (1.延安大学附属医院心内科一病区，陕西延安 716000；2.陕西省理工学校，陕西西安 710000)

Author(s):: ZHANG Yue¹; MA Xiao-chuan¹; ZHANG Tao¹; YAO Liang²; (1.First Department of Cardiology, Affiliated Hospital to Yan’an University, Yan’an 716000, Shaanxi, China; 2.Shaanxi Polytechnic School, Xi’an 710000, Shaanxi, China)

关键词:: 高密度脂蛋白; 动脉粥样硬化; 机制

Keywords:: high-density lipoprotein; atherosclerosis; mechanism

分类号:: Q513.5

DOI:: -

文献标识码:: A

摘要:: 近几年的一些研究认为，在一些疾病中（如Ⅱ型糖尿病及代谢综合征及系统性红斑狼疮等），一直被誉为“好脂蛋白”的高密度脂蛋白（HDL）不仅血浆水平降低，其结构还会发生改变进而功能逆转，加速了动脉粥样硬化（AS）的发展，提高心血管病的风险。因此，阐明失功能性HDL在疾病状态中致AS的机制将有助于心血管疾病的预防与治疗，本文就功能性和失能性HDL的抗AS作用进行了综述。

Abstract:: In recent years it has been found that high-density lipoprotein, hailed as “good LDL” in some studies, is reduced and its structure changes in some diseases such as type 2 diabetes, metabolic syndrome, and systemic lupus erythematosus. The reversed function accelerates the development of atherosclerosis and enhances risks of cardiovascular disease. This paper reviewed the anti-atherosclerosis mechanism of functional and dysfunctional high-density lipoprotein.

参考文献/References

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失功能性高密度脂蛋白致动脉粥样硬化的机制(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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