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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2012年第5期

页码:

588-590

栏目:

基础研究

出版日期:

2012-10-25

文章信息/Info

Title:

Effects of sodium ozagrel on vasopressin-induced myocardial ischemia in rats

作者:

程景林¹; 王 琼²

(1.安徽医科大学第二附属医院急诊内科 安徽 合肥 230601；
2.解放军第105医院干部病房，安徽 合肥 230031)

Author(s):

CHENG Jing-lin¹;  WANG Qiong²

(1.Emergency Department, Second Affiliated Hospital, Anhui Medical University, Hefei 230601, Anhui, China; 2.Department of Cardiology, PLA 105 Hospital, Hefei 230031, Anhui, China)

关键词:

奥扎格雷钠; 垂体后叶素; 心肌缺血; 抗氧化; 血小板因子4; 大鼠

Keywords:

sodium ozagrel;  vasopressin;  myocardial ischemia;  antioxidant;  platelet factor

分类号:

Q575.3

DOI:

-

文献标识码:

A

摘要:

目的:研究奥扎格雷钠(sodium ozagrel，S-OZA)对垂体后叶素(pituitrin，PIT)所致大鼠心肌缺血模型的保护作用及机制。方法： 采用PIT建立大鼠心肌缺血模型，观察S-OZA对大鼠心电图(ECG)、血清超氧化物歧化酶(SOD)、丙二醛(MDA)水平及血小板因子4(PF4)的影响。结果： S-OZA可抑制PIT引起的T波改变，降低血清MDA及PF4的水平，升高SOD的水平。结论： S-OZA对垂体后叶素所致大鼠缺血心肌具有一定的保护作用，其机制与其抗氧化、抗PF4等有关。

Abstract:

AIM:To investigate the effects of sodium ozagrel on vasopressin-induced myocardial ischemia and its mechanisms. METHODS: Myocardial ischemia was induced by vasopressin injection in rats. The effects of sodium ozagrel on ECG, malondialdehyde (MDA) level, superoxide dismutase (SOD) activity and PF4 in sera were observed. RESULTS: Sodium ozagrel significantly inhibited the changes of T-wave, lowered the level of MDA, increased SOD level and decreased the PF4 level in sera of rats with myocardial ischemia. CONCLUSION: Sodium ozagrel has some type of protective effect on vasopressin-induced myocardial ischemia, possibly through its effects on antioxidant and antiplatelet factor PF4.

参考文献/References

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备注/Memo

备注/Memo:

收稿日期：2011-12-12.
作者简介：程景林，副主任医师，博士生Email:chjl201102@163.com

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更新日期/Last Update: 2012-11-16