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|本期目录/Table of Contents|

代谢综合征患者的P波时限及离散度分析

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第6期
页码:
723-725
栏目:
临床研究
出版日期:
2012-12-25

文章信息/Info

Title:
P-wave duration and dispersion in patients with metabolic syndrome
作者:
丁跃有; 崔克俭; 郑宏超; 缪培智; 卞士平; 顾水明
(上海徐汇区中心医院，上海 200031)
Author(s):
DING Yue-you;  CUI Ke-jian;  ZHENG Hong-chao;  MIU Pei-zhi;  BIAN Shi-ping;  GU Shui-ming
(Department of Cardiology, Xuhui District Central Hospital, Shanghai 200031, China)
关键词:
离散度; P波; 代谢综合征
Keywords:
P-wave dispersion;  metabolic syndrome
分类号:
R589
DOI:
-
文献标识码:
A
摘要:
目的:观察代谢综合征患者的P波时限及离散度(PWD)。方法： 选择代谢综合征患者62（男34，女28）例，年龄（55±8）岁；非代谢综合征（对照）组58（男30，女28）例，年龄（55±9）岁。代谢综合征诊断标准：符合国际糖尿病联盟（IDF）代谢综合征定义。以中心性肥胖为基本条件(根据腰围判断)，中国人群腹围确定主要基于中国上海市和香港的流行病学资料，男性≥90 cm,女性≥80 cm。所有患者进行12导联同步描记心电图。PWD是指体表心电图12导联中测定的P波最大时限与最小时限的差值。所有的受试者同时接受超声心动图检查。结果： 代谢综合征组P波最大时限和PWD明显高于对照组［P波最大时限：(112±8) ms vs.(98±9) ms；PWD：(37±7) ms vs.(23±5) ms，均P<0.01］，而两组P波最小时限差异无显著意义。相关分析提示PWD与年龄、体质量指数、腰围、收缩压、舒张压、总胆固醇、三酰甘油呈正相关，而与高密度脂蛋白胆固醇呈负相关。进一步行多元线性回归分析表明，年龄（β=0.394，P<0.01）、体质量指数（β=0.22，P<0.01）、腰围（β=0.165，P<0.05）、收缩压（β=0.166，P=0.01）、总胆固醇（β=0.195，P<0.01）和三酰甘油（β=0.227，P<0.01）是PWD的独立危险因素。结论： 代谢综合征组患者PWD明显高于对照组,提示P波离散度增加可能是代谢综合征患者房颤发生率增高的机制之一。
Abstract:
AIM:To investigate P-wave dispersion (PWD) in patients with metabolic syndrome (MetS). METHODS: Sixty-two patients with MetS ［34 males, 28 females; mean age (55.2±8.2) years］ and 58 control subjects without MetS (30 males, 28 females; mean age 54.6±8.7 years) were recruited. MetS diagnosis was based on the International Diabetes Federation MetS criteria and central obesity was evaluated by waist circumference (≥90 cm in male and ≥80 cm in females) according to the epidemiological data from Shanghai and Hong Kong in China. A 12-lead electrocardiogram was recorded for each subject. The difference between the maximum and minimum P-wave duration was calculated and defined as PWD. Echocardiographic examination was also performed for each subject. RESULTS: Maximum P-wave duration and PWD were significantly higher in patients with MetS compared with control subjects ［maximum P-wave duration (112±8) msec vs.(98±9) msec, PWD (37±7) msec vs.(23±5) msec, P<0.01 for both］. However, no statistically significant difference in the minimum P-wave duration was found between the groups. In addition, PWD was positively correlated with age, body mass index, waist circumference, systolic and diastolic blood pressure, total cholesterol and triglyceride levels, but was negatively correlated with high-density lipoprotein cholesterol level. Multiple linear regression analysis showed that age (β=0.394, P<0.01,) BMI (β=0.22, P=0.002), waist circumference (β=0.165, P=0.02), systolic blood pressure (β=0.166, P=0.012), total cholesterol (β=0.195, P=0.009) and triglyceride level (β=0.227, P=0.004) were independent risk factors of PWD. CONCLUSION: Patients with MetS have higher PWD, which may be responsible for increased risk for atrial fibrillation.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2012-03-02.作者简介：丁跃有，主治医师，硕士 Email：dingyueyou@gmail.com
更新日期/Last Update: 2012-12-30