热休克蛋白70在心力衰竭患者中的研究进展
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2013年第5期
- 页码:
- 586-588591
- 栏目:
- 综述
- 出版日期:
- 2013-09-25
文章信息/Info
- Title:
- Research progress on heat shock protein 70 in patients with heart failure
- Author(s):
- TIAN Ni ni1; 2; WEI Ling1
- (1.Wards for Civilian Cadres, Kunming General Hospital, Chengdu Military Area Command, Kunming 650032, Yunnan, China; 2.Graduate School, Kunming Medical University, Kunming 650032, Yunnan, China)
- Keywords:
- heat shock protein 70; heart failure
- 分类号:
- Q51
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 热休克蛋白（heat shock protein，HSP）在生物应激反应中具有保护细胞免受损伤的作用。大部分研究集中在这种重要的蛋白质家族在哺乳动物细胞对急性应激反应的作用机制。HSP70循环存在于正常健康个体及患有多种严重疾病的患者中，包括心力衰竭（HF）。HSP70在慢性心力衰竭（CHF）患者中是升高的，特别是在严重的晚期HF患者中。HSP70反映的是疾病的严重程度而非生存率。HSP70的表达在发病率中的重要关系有待进一步评估。
- Abstract:
- Heat shock protein (HSP) constitutes an endogenous stress response that protects cells from injury. Most research on this important protein has focused on the immediate response to acute stress in cell culture systems and mammalians. Circulating HSP70 is present in the circulation of healthy individuals and in patients with various disorders, including heart failure (HF). HSP70 levels are elevated in chronic HF patients, particularly in those with cardiac cachexia. HSP70 relates to the disease severity and not to the survival rate. The significance of the relationship of HSP70 expression and morbidity in HF needs further evaluation.
参考文献/References
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[2] Mamoru S,Yudai S,Tomonari A,et al.Elevated circulating levels of heat shock protein 70 are related to systemic inflammatory reaction through monocyte toll signal in patients with heart failure after acute myocardial infarction[J].Eur J Heart Fail,2006,8(8):810- 815.
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[7]尹晓姝，李林峰.血清热休克蛋白70与急性心肌梗死后心力衰竭的相关性［J］. 心血管病学进展, 2011, 32(4):597-600.
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[9]Wei YJ,Huang YX,Shen Y. Proteomic analysis reveals significant elevation of heat shock protein 70 in patients with chronic heart failure due to arrhythmogenic right ventricular cardiomyopathy[J].Mol Cell Biochem,2009,332(1-2):103-111.
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备注/Memo
- 备注/Memo:
- 收稿日期：2013-03-27.通讯作者：魏玲，主任医师，主要从事心血管疾病研究 Email:weilling43@yahoo.com.cn 作者简介：田倪妮，硕士生 Email:70326943@qq.com
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