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|本期目录/Table of Contents|

AMPK-能量代谢感受器与可激活AMPK相关的药物研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第1期
页码:
97-100
栏目:
综述
出版日期:
2013-12-02

文章信息/Info

Title:
New findings in AMP-activated protein kinase
作者:
耿凤豪1; 张 鹏2; 董 玲1; 高 峰1
(1.第四军医大学基础部生理学教研室，陕西 西安 710032；2.兰州军区乌鲁木齐总医院骨科，新疆 乌鲁木齐 83000)
Author(s):
GENG Feng-hao1;  ZHANG Peng2;  DONG Ling1;  GAO Feng1
(1.Department of Physiology, Fourth Military Medical University, Xi’an 710032, Shaanxi, China; 2.Department of Orthopedic Surgery, Urumqi General Hospital, Urumqi 830000, Xinjiang, China)
关键词:
单磷酸腺苷活化蛋白激酶; 细胞代谢; 炎症; 肿瘤; 胰岛素抵抗
Keywords:
AMP-activated protein kinase;  metabolism;  inflammation;  tumor;  insulin resistance
分类号:
Q25;Q51
DOI:
-
文献标识码:
A
摘要:
单磷酸腺苷活化蛋白激酶(AMPK)可以感受细胞能量代谢变化，调节细胞的葡萄糖、脂肪酸的代谢过程。AMPK与细胞生长、生存和多种代谢信号途径关系密切，研究发现AMPK信号途径涉及炎症、肿瘤和代谢疾病。本文综述AMPK的功能与炎症、肿瘤、代谢类疾病的关系和诸如水杨酸、二甲双胍等药物激活AMPK的研究进展。
Abstract:
A sensor of cellular energy status, the AMP-activated protein kinase (AMPK) exerts some effects on the modulation of glucose and lipid metabolism, which is highly related with cell viability and survival. AMPK is also activated by drugs such as metformin and salicylate. In addition, studies have shown that AMPK also exerts a wide range of effects on the signaling pathways including inflammation, cancer and metabolic disorders. The article focuses on the new findings of AMPK.

参考文献/References

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[10]姚 远,毕生辉,冯建宇,等.AMPK抑制剂P5499拮抗无钙预处理心肌保护作用[J].心脏杂志,2012,24(1):12-16.

备注/Memo

备注/Memo:
收稿日期：2013-06-24.基金项目：国家科技重大专项课题资助（2009ZX09301-009）；陕西省中医管理局中医药科研课题资助（jc 38） 通讯作者：董玲，副教授，主要从事糖尿病与心血管损害研究 Email：dongling@fmmu.edu.cn 作者简介：耿凤豪，本科生 Email：gengfenghao@163.com
更新日期/Last Update: 2014-01-20