白介素-18与心血管疾病
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2014年第1期
- 页码:
- 101-103
- 栏目:
- 综述
- 出版日期:
- 2013-12-02
文章信息/Info
- Title:
- Interleukin-18 and cardiovascular diseases
- Author(s):
- FU Lin; LUAN Ying
- (Department of Cardiology, Second Affiliated Hospital, Harbin Medical University, Harbin 150086, Heilongjiang, China)
- 分类号:
- R392.12
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 心血管疾病在现代社会中严重威胁人类健康,死亡率高。近年来,随着基因组学、蛋白质学和生物学的研究发展,确定心血管疾病的生物学标志物已经成为一种迫切需要,因为其能够客观反映生物学进程、发病机制和药理学改变,并可能成为可测定或评估的特征性指标。白介素-18（interleukin-18，IL-18）是近年来发现的具有多种生物学特性的炎性细胞因子,其作为细胞因子的重要成员在炎症过程中起重要作用。越来越多的实验和临床证据表明,IL-18在心血管疾病的发生、发展、预后及并发症中扮演着重要的角色。本文就IL-18与冠心病、高血压病、心力衰竭、房颤的关系作简要综述。
- Abstract:
- Cardiovascular diseases in modern society have a high mortality and pose serious threats to human health. With the development of genomics, there is an urgent need for identified biomarkers of cardiovascular diseases. Biomarkers of cardiovascular diseases can objectively reflect the biological process, pathogenesis and changes in pharmacology. Biomarkers of cardiovascular diseases may become important indicators. Interleukin-18 (IL-18) with many biological characteristics of inflammatory cytokines serves as an important member of the cytokines and plays a significant role in the inflammatory process. An increasing number of experiments and clinical evidence suggest that IL-18 is important in the occurrence, development, prognosis and complications of cardiovascular diseases. In this paper we will briefly review the relationship between IL-18 and coronary heart disease, hypertension, heart failure and atrial fibrillation.
参考文献/References
[1]Kawayama T,Okamoto M,Imaoka H,et al.Interleukin-18 in pulmonary inflammatory diseases[J].Cytokine Research,2012,32(10):443-449.
[2]Eslick GD,Thampan BV,Nalos M,et al.Circulating interleukin-18 concentrations and a loss-of-function P2X7 polymorphism in heart failure[J].Internal J Cardiol,2009,137(1):81-83.
[3]Matsumoto M,Tsujino T,Lee-Kawabata M,et al.Serum interleukin-6 and C-reactive protein are markedly elevated in acute decompensated heart failure patients with left ventricular systolic dysfunction[J].Cytokine,2010,49(3):264-268.
[4]Orn S,Ueland T,Manhenke C,et al.Increased interleukin-1β levels are associated with left ventricular hypertrophy and remodelling following acute ST segment elevation myocardial infarction treated by primary percutaneous coronary intervention[J].J Intern Med,2012,272(3):267-276.
[5]Xing SS,Bi XP,Tan HW,et al.Overexpression of interleukin-18 aggravates cardiac fibrosis and diastolic dysfunction in fructose-fed rats[J].Mol Med,2010,16(11-12):465-470.
[6]Wang M,Markel TA,Meldrum DR.Interleukin 18 in the heart[J].Shock,2008,30(1):3-10.
[7]Tatsukawa Y,Hsu WL,Yamada M,et al.White blood cell count,especially neutrophil count,as a predictor of hypertension in a Japanese population[J].Hypertension Res,2008,31(7):1391-1397.
[8]Rabkin SW.The role of interleukin 18 in the pathogenesis of hypertension-induced vascular disease［J］. Nature Clin Practice Cardiovasc Med,2009,6(3):192-199.
[9]Zhang Z,Kyttaris VC,Tsokos GC.The role of IL-23/IL-17 axis in lupus nephritis[J].J Immunol,2009,183(5):3160-3169.
[10]Alegret JM,Aragones G,Elosua R,et al.The relevance of the association between inflammation and atrial fibrillation[J].Eur J Clin Invest,2013,43(4):324-331.
[11]Yamashita T,Sekiguchi A,Iwasaki YK,et al.Recruitment of immune cells across atrial endocardium in human atrial fibrillation[J]. Circulation J,2010,74(2):262-270.
[12]Luan Y,Guo Y,Li S,et al.Interleukin-18 among atrial fibrillation patients in the absence of structural heart disease[J].Europace,2010,12(12):1713-1718.
备注/Memo
- 备注/Memo:
- 收稿日期：2013-06-25.基金项目：国家自然科学基金项目（青年科学基金）资助(81200130) 通讯作者：栾颖，主任医师，主要从事心律失常的基础及临床研究 Email：drluanying@163.com 作者简介：付琳，硕士生 Email：fulin19862003@aliyun.com
常用功能
统计/Statistics
- 摘要浏览/Viewed875
- 评论/Comments
