我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

内源性心脏干/祖细胞活化的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2015年第3期
页码:
357-360
栏目:
综述
出版日期:
2015-01-11

文章信息/Info

Title:
Advance in activation of endogenous cardiac stem/progenitor cells
作者:
郭 涛; 刘 通; 曹 丰
(第四军医大学西京医院心内科，陕西 西安 710032)
Author(s):
GUO Tao;  LIU Tong;  CAO Feng
(Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
内源性心肌干/祖细胞; 心肌梗死; 细胞疗法
Keywords:
endogenous cardiac stem cell;  cardiac progenitor cell;  myocardial infarction;  cellular therapy
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
随着现代生活方式的改变和老龄化的问题，心血管疾病已成为威胁人类健康的第一杀手。然而当前医疗诊治技术仍难以彻底改善心肌梗死后缺血性心肌病及心力衰竭患者的预后。干细胞的出现为心肌再生带来了新的希望。与其他成体干细胞相比，内源性心脏干细胞(CSCs)具有分化成心肌细胞和血管内皮细胞的潜能，可对受损心肌起到明显的修复作用。研究发现，心肌梗死后内源性CSCs的激活与多种因素有关。最近几年，内源性CSCs活化介导的心肌修复引起了研究人员极大的兴趣。本文将对CSCs激活所涉及的主要途径进行论述，以深化对内源性CSCs功能的理解。
Abstract:
Cardiovascular disease (CVD) is the leading cause of mortality with changing lifestyles and aging problems. But the rapid development of modern technology still cannot meet the need for diagnosis and treatment of myocardial infarction. Stem cell therapy offers renewed hope for cardiac regeneration. Compared with other adult stem cells, endogenous cardiac stem cells (CSCs) can differentiate into cardiomyocytes and vascular endothelial cells, thus having the potential to repair damaged cardiac cells. Research has shown that multiple factors are involved in the process of CSCs activation. In recent years, endogenous CSC-mediated cardiac repair has become the new focus in fields of cardiac regeneration and tissue engineering. In this review, we discuss the main pathways that mediate CSCs activation so as to elucidate in vivo functions of endogenous CSCs.

参考文献/References

[1]Rosamond W,Flegal K,Friday G,et al.Heart disease and stroke statistics--2007 update:a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee[J].Circulation,2007,115(5):e69-e171.
[2]Sutton MG,Sharpe N.Left ventricular remodeling after myocardial infarction: pathophysiology and therapy[J].Circulation,2000,101(25):2981-2988.
[3]Makino S,Fukuda K,Miyoshi S,et al.Cardiomyocytes can be generated from marrow stromal cells in vitro[J].J Clin Invest,1999,103(5):697-705.
[4]Ahmed RP,Ashraf M,Buccini S,et al.Cardiac tumorigenic potential of induced pluripotent stem cells in an immunocompetent host with myocardial infarction[J].Regen Med,2011,6(2):171-178.
[5]Pfister O,Mouquet F,Jain M,et al.CD31-but not CD31+cardiac side population cells exhibit functional cardiomyogenic differentiation[J].Circ Res,2005,97(1):52-61.
[6]Williams AR,Hatzistergos KE,Addicott B,et al.Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction[J].Circulation,2013,127(2):213-223.
[7]Urbanek K,Quaini F,Tasca G,et al.Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy[J].Proc Natl Acad Sci U S A,2003,100(18):10440-10445.
[8]Sussman MA,Anversa P.Myocardial aging and senescence:where have the stem cells gone?[J].Annu Rev Physiol,2004,66:29-48.
[9]Anversa P,Sussman MA,Bolli R.Molecular genetic advances in cardiovascular medicine:focus on the myocyte[J].Circulation,2004,109(23):2832-2838.
[10]Leri A,Kajstura J,Anversa P.Cardiac stem cells and mechanisms of myocardial regeneration[J].Physiol Rev,2005,85(4):1373-1416.
[11]Torella D,Indolfi C,Goldspink DF,et al.Cardiac stem cell-based myocardial regeneration:towards a translational approach[J].Cardiovasc Hematol Agents Med Chem,2008,6(1):53-59.
[12]Suzuki G,Iyer V,Cimato T,et al. Pravastatin improves function in hibernating myocardium by mobilizing CD133+ and cKit+ bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle[J].Circ Res,2009,104(2):255-264,10p following 264.
[13]Kanashiro-Takeuchi RM,Takeuchi LM,Rick FG,et al.Activation of growth hormone releasing hormone(GHRH)receptor stimulates cardiac reverse remodeling after myocardial infarction(MI)[J].Proc Natl Acad Sci U S A,2012,109(2):559-563.
[14]Ellison GM,Torella D,Karakikes I,et al.Acute beta-adrenergic overload produces myocyte damage through Calcium leakage from the ryanodine receptor 2 but spares cardiac stem cells[J].J Biol Chem,2007,282(15):11397-11409.
[15]Itzhaki-Alfia A,Leor J,Raanani E,et al.Patient characteristics and cell source determine the number of isolated human cardiac progenitor cells[J]. Circulation,2009,120(25):2559-2566.
[16]Hoch M,Fischer P,Stapel B,et al.Erythropoietin preserves the endothelial differentiation capacity of cardiac progenitor cells and reduces heart failure during anticancer therapies[J].Cell Stem Cell,2011,9(2):131-143.
[17]Wan J,Deng Y,Guo J,et al.Hyperhomocysteinemia inhibited cardiac stem cell homing into the peri-infarcted area post myocardial infarction in rats[J].Exp Mol Pathol,2011,91(1):411-418.
[18]Gaetani R,Ledda M,Barile L,et al.Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields[J].Cardiovasc Res,2009,82(3):411-420.
[19]Ferreira-Martins J,Rondon-Clavo C,Tugal D,et al.Spontaneous Calcium oscillations regulate human cardiac progenitor cell growth[J].Circ Res,2009,105(8):764-774.
[20]Nadal-Ginard B,Anversa P,Kajstura J,et al.Cardiac stem cells and myocardial regeneration[J].Novartis Zound Symp,2005,265:142-154; discussion 155-157,204-211.
[21]Torella D,Ellison GM,Karakikes I,et al.Resident cardiac stem cells[J].Cell Mol Life Sci,2007,64(6):661-673.
[22]Padin-Iruegas ME,Misao Y,Davis ME,et al.Cardiac progenitor cells and biotinylated insulin-like growth factor-1 nanofibers improve endogenous and exogenous myocardial regeneration after infarction[J].Circulation,2009,120(10):876-887.
[23]Fatma S,Selby DE,Singla RD,et al.Factors released from embryonic stem cells stimulate c-kit-FLK-1(+ve) progenitor cells and enhance neovascularization[J].Antioxid Redox Signal,2010,13(12):1857-1865.
[24]Linke A,Müller P,Nurzynska D,et al.Stem cells in the dog heart are self-renewing,clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function[J].Proc Natl Acad Sci U S A,2005,102(25):8966-8971.
[25]Ellison GM,Torella D,Dellegrottaglie S,et al.Endogenous cardiac stem cell activation by insulin-like growth factor-1/hepatocyte growth factor intracoronary injection fosters survival and regeneration of the infarcted pig heart[J].J Am Coll Cardiol,2011,58(9):977-986.
[26]D’amario D,Cabral-Da-Silva MC,Zheng H,et al.Insulin-like growth factor-1 receptor identifies a pool of human cardiac stem cells with superior therapeutic potential for myocardial regeneration[J].Circ Res,2011,108(12):1467-1481.
[27]Kawaguchi N,Smith AJ,Waring CD,et al.C-kitpos GATA-4 high rat cardiac stem cells foster adult cardiomyocyte survival through IGF-1 paracrine signalling[J].PLoS One,2010,5(12):e14297.
[28]Chimenti I,Smith RR,Li TS,et al.Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice[J].Circ Res,2010,106(5):971-980.
[29]Miyamoto S,Kawaguchi N,Ellison GM,et al.Characterization of long-term cultured c-kit+ cardiac stem cells derived from adult rat hearts[J].Stem Cells Dev,2010,19(1):105-116.
[30]Torella D,Rota M,Nurzynska D,et al.Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression[J].Circ Res,2004,94(4):514-524.
[31]Tang J,Wang J,Kong X,et al.Vascular endothelial growth factor promotes cardiac stem cell migration via the PI3K/Akt pathway[J]. Exp Cell Res,2009,315(20):3521-3531.
[32]Tateishi K,Ashihara E,Honsho S,et al.Human cardiac stem cells exhibit mesenchymal features and are maintained through Akt/GSK-3beta signaling[J].Biochem Biophys Res Commun,2007,352(3):635-641.
[33]Li M,Naqvi N,Yahiro E,et al.C-kit is required for cardiomyocyte terminal differentiation[J].Circ Res,2008,102(6):677-685.
[34]Forte G,Carotenuto F,Pagliari F,et al.Criticality of the biological and physical stimuli array inducing resident cardiac stem cell determination[J].Stem Cells,2008,26(8):2093-2103.
[35]Di Nardo P,Forte G,Ahluwalia A,et al.Cardiac progenitor cells: potency and control[J].J Cell Physiol,2010,224(3):590-600.
[36]Ellison GM,Galuppo V,Vicinanza C,et al.Cardiac stem and progenitor cell identification:different markers for the same cell?[J].Front Biosci(Schol Ed),2010,2:641-652.

备注/Memo

备注/Memo:
收稿日期：2014-05-28.
基金项目：国家杰出青年基金项目资助（81325009）；国家自然科学基金项目资助（81270168）
通讯作者：曹丰，教授，主要从事心血管分子影像研究Email：wind8828 @ gmail.com
作者简介：郭涛，硕士生Email：guotao19871228@163.com
更新日期/Last Update: 2015-02-03