冠心病患者内皮祖细胞数量及功能变化的研究进展
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2015年第3期
- 页码:
- 361-364
- 栏目:
- 综述
- 出版日期:
- 2015-01-11
文章信息/Info
- Title:
- Research progress in number and functional changes of endothelial progenitor cells in patients with coronary heart disease
- Author(s):
- MAI Chao-ping; HA Xiao-qin; GAO Cai-yan
- (Department of Laboratory Medicine, PLA General Hospital, Lanzhou Military Area Command, Lanzhou 730050, Gansu, China)
- 分类号:
- R543
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 冠心病(CHD)是现代社会严重威胁人类健康的主要疾病之一，且病死率高。动脉粥样硬化（AS）是其病理基础。而内皮细胞的损伤与CHD的发生发展关系密切。血管内皮祖细胞(endothelial progenitor cells，EPCs)作为内皮细胞的前体细胞，在组织缺血及血管损伤时动员入血，参与微血管的生成及血管内皮的修复，在冠心病发生及发展过程中起着非常重要的作用。已经证明EPCs数量下降及功能减退与CHD发病有密切关系,现将冠心病患者外周血内皮祖细胞数量及功能的变化情况做一详细阐述。
- Abstract:
- Coronary heart disease (CHD) poses one of the most serious threats to human health with high mortality. Atherosclerosis is the pathological cause of CHD and the development of endothelial cell damage is closely related with CHD. As a precursor cell of endothelial cells, endothelial progenitor cells (EPCs) play a vital role in tissue ischemia in mobilizing the cells into blood to generate capillaries and to repair microvascular endothelium in the course of vascular injury or damage and in the process of occurrence and development of CHD. It has been proven that the decrease in the number of EPCs and their dysfunction have a close relationship with the incidence of CHD. This article will elaborate on the changes in the number and dysfunction of endothelial progenitor cells in peripheral blood in patients with coronary heart disease.
参考文献/References
[1]Yang Z,von Ballmoos MW,Faessler D,et al.Paracrine factors secreted by endothelial progenitor cells prevent oxidative stress-induced apoptosis of mature endothelial cells[J].Atherosclerosis,2010,211(1):103-109.
[2]Mourino-Alvarez L,Calvo E,Moreu J,et al.Proteomic characterization of EPCs and CECs“in vivo”from acute coronary syndrome patients and control subjects[J].Biochim Biophys Acta,2013,1830(4):3030-3053.
[3]Zhang Q, Kandic I,Kutryk MJ.Dysregulation of angiogenesis-related microRNAs in endothelial progenitor cells from patients with coronary artery disease[J].Biochem Biophys Res Commun,2011,405(1):42-46.
[4]Hristov M,Weber C.Ambivalence of progenitor cells in vascular repair and plaque stability[J].Curr Opin Lipidol,2008,19(5):491-497.
[5]Hagensen MK,Shim J,Thim T,et al.Circulating endothelial progenitor cells do not contribute to plaque endothelium in murine atherosclerosis[J].Circulation,2010,121(7):898-905.
[6]方叶青,张松荣,方红城,等.冠心病患者内皮祖细胞变化与冠状动脉病变的相关性[J].中国动脉硬化杂志,2012,20(9):814-818.
[7]Liao YF,Feng Y,Chen LL,et al.Coronary heart disease risk equivalence in diabetes and arterial diseases characterized by endothelial function and endothelial progenitor cell[J].J Diabetes Complications,2014,28(2):214-218.
[8]Di Mambro A,Ferlin A,De Toni L,et al.Endothelial progenitor cells as a new cardiovascular risk factor in Klinefelter’s syndrome[J].Mol Hum Reprod,2010,16(6):411-417.
[9]Asahara T,Kawamoto A,Masuda H.Circulating endothelial progenitor cells for vascular medicine[J].Stem Cells,2011,29(11):1650-1655.
[10]黄树斌.冠心病患者HCY与内皮祖细胞功能及表达水平相关变化分析[J].现代预防医学,2012,39(5):1271-1273.
[11]Imanishi T,Moriwaki C,Hano T,et al.Endothelial progenitor cell senescence is accelerated in both experimental hypertensive rats and patients with essential hypertension[J].J Hypertens,2005,23(10):1831-1837.
[12]Zhou Z,Peng J,Wang CJ,et al.Accelerated senescence of Endothelial progenitor cells in hypertension is related to the reduction of calcitonin gene-related peptide[J].Hypertens,2010,28(5):931.
[13]Lenk K,Uhlemann M,Schuler G,et al Role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease[J].J Appl Physiol,2011,111(1):321-328.
[14]Waksman R,Baffour R,Pakala R,et al.Effects of exogenous peripheral-blood-derived endothelial progenitor cells or unfractionated bone-marrow-derived cells on neointimal formation and inflammation in cholesterol-fed, balloon-denuded, and radiated iliac arteries of inbred rabbits[J].Cardiovasc Revasc Med,2009,10(2):110-116.
[15]Xu DY,Davis BB,Wang ZH,et al.A potent soluble epoxide hydrolase inhibitor, t-AUCB, acts through PPARγ to modulate the function of endothelial progenitor cells from patients with acute myocardial infarction[J].Int J Cardiol,2013,167(4):1298-1304.
[16]Chen BS,Xie H,Zhang SL,et al.Tissueengineeringof bladder using vascular endothelial growth factor gene-modified endothelialprogenitor cells[J].Int JArtif Organs,2011,34(12):1137-1146.
备注/Memo
- 备注/Memo:
- 收稿日期：2014-04-23.
基金项目：国家自然科学基金项目资助(81060015)；甘肃省自然基金项目资助(110TRJ2A114)
通讯作者：哈小琴，主任医师，主要从事干细胞和基因药物研究Email：287244870@qq.com
作者简介：买超平，硕士生Email：287244870@qq.com
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