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|本期目录/Table of Contents|

阿托伐他汀对犬心房及肺静脉电活动的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第2期
页码:
157-159
栏目:
基础研究
出版日期:
2015-11-25

文章信息/Info

Title:
Effects of atorvastatin on atrial and pulmonary vein electrical activity
作者:
石铭宇; 滕世超; 姜 丽; 朱 静; 尹 峰; 谷宏越
(哈尔滨医科大学附属第一医院心内科，黑龙江 哈尔滨 150001）
Author(s):
SHI Ming-yu;  TENG Shi-chao;  JIANG Li;  ZHU Jing;  YIN Feng;  GU Hong-yue
(Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China)
关键词:
心房颤动; 阿托伐他汀; 有效不应期
Keywords:
atrial fibrillation;  atorvastatin;  effective refractory period
分类号:
R541.7
DOI:
-
文献标识码:
A
摘要:
目的 观察阿托伐他汀对犬心房及肺静脉电活动的影响。方法 将实验动物犬随机分为对照组(n=7)和试药组(n=7)，其中试药组于术前4周每天服用阿托伐他汀（2 mg/kg）直至术前结束。之后分别测各组犬心房及肺静脉不应期，并进行房颤的诱发。结果 试药组犬的心房各部位不应期均较对照组延长，频率适应性较对照组提高。在房颤的诱发中，试药组房颤的诱发率较对照组低。 结论 阿托伐他汀可有效改善犬的心房电活动，从而对房颤的发生及复发起到抑制作用。
Abstract:
AIM To observe the effects of atorvastatin on atrial and pulmonary vein electrical activity. METHODS Fourteen dogs were randomly divided into the control group (n=7) and the atorvastatin group (n=7), and atorvastatin was administered orally (2 mg/kg/day) 4 weeks before operation. The atrial effective refractory period (AERP) and pulmonary vein effective refractory period (AERP) were determined. RESULTS Atorvastatin group had a longer AERP and a longer AERP rate adapting feature. In induced atrial fibrillation, the atorvastin group had a lower rate than the control group. CONCLUSION Atorvastatin effectively improves the atrial electrical activity and reduces the occurrence and recurrence of atrial fibrillation.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2015-03-16.
基金项目：黑龙江省教育厅科学技术研究项目资助(12511306)
通讯作者：谷宏越，副主任医师，主要从事心脏电生理研究 Email：shimy1974@163.com
作者简介：石铭宇，主治医师，博士生 Email:shimingyu1974@sina.com
更新日期/Last Update: 2016-04-25