我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

胰岛素抵抗与心力衰竭关系的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第3期
页码:
352-355,F003
栏目:
综述
出版日期:
2016-01-05

文章信息/Info

Title:
Research progress on the relationship between insulin resistance and heart failure
作者:
梁 鹏1; 张松飞1; 王 珂1; 刘成峰1; 付 锋2
（第四军医大学：1.学员旅，2.基础部生理学教研室，陕西 西安 710032）
Author(s):
LIANG Peng1;  ZHANG Song-fei1;  WANG Ke1;  LIU Cheng-feng1;  FU Feng2
(1.Cadet Brigade, 2.Department of Physiology, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
心力衰竭; 胰岛素抵抗; 神经内分泌; 能量代谢
Keywords:
heart failure;  insulin resistance;  neuroendocrine;  energy metabolism
分类号:
R458
DOI:
-
文献标识码:
A
摘要:
胰岛素抵抗(IR)是指机体组织细胞对胰岛素的敏感性下降的一种状态。研究发现IR与心力衰竭(heart failure, HF)密切相关，IR可促进HF的发生发展，HF的加重也可反过来促进IR，IR和HF的恶性循环会不断导致HF的恶化和IR的加重。本文简要介绍了IR与心力衰竭关系的研究进展。
Abstract:
Insulin resistance (IR) is a state in which body tissues have a lowered level of response to insulin. Studies have found a close relationship between IR and heart failure (HF). IR contributes to the development of heart failure and aggravated heart failure can promote the development of IR. This vicious cycle between IR and heart failure may cause the deterioration of heart failure and the promotion of IR. This article reviews the research progress in the relationship between IR and heart failure.

参考文献/References

[1]Defronzo RA,Tobin JD,Andres R.Glucose clamp technique:a method for quantifying insulin secretion and resistance[J].Am J Physiol,1979,237(3):E214-E223.
[2]Bergman RN,Prager R,Volund A,et al.Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp[J].J Clin Invest,1987,79(3):790-800.
[3]李光伟,潘孝仁.检测人群胰岛素敏感性的一项新指数[J].中华内科杂志,1993,32(10):656-660.
[4]Kannel WB,Hjortland M,Castelli WP.Role of diabetes in congestive heart failure: the Framingham study[J].Am J Cardiol,1974,34(1):29-34.
[5]Wong C,Marwick TH.Obesity cardiomyopathy:pathogenesis and pathophysiology[J].Nat Clin Pract Cardiovasc Med,2007,4(8):436-443.
[6]Witteles RM,Fowler MB.Insulin-resistant cardiomyopathy clinical evidence,mechanisms, and treatment options[J].J Am Coll Cardiol,2008,51(2):93-102.
[7]Ingelsson E,Sundstrom J,Arnlov J,et al.Insulin resistance and risk of congestive heart failure[J].JAMA,2005,294(3):334-341.
[8]Gibbs CL.Cardiac energetics[J].Physiol Rev,1978,58(1):174-254.
[9]Stanley WC,Recchia FA,Lopaschuk GD.Myocardial substrate metabolism in the normal and failing heart［J］. Physiol Rev, 2005, 85(3):1093-1129.
[10]Opie LH. The metabolic vicious cycle in heart failure［J］. Lancet, 2004, 364(9447):1733-1734.
[11]Rider MH, Hue L. Activation of rat heart phosphofructokinase-2 by insulin in vivo［J］. FEBS Lett, 1984, 176(2):484-488.
[12]Gamble J, Lopaschuk GD. Insulin inhibition of 5′ adenosine monophosphate-activated protein kinase in the heart results in activation of acetyl coenzyme A carboxylase and inhibition of fatty acid oxidation［J］. Metabolism, 1997, 46(11):1270-1274.
[13]Beutler B, Cerami A. Cachectin: more than a tumor necrosis factor［J］. N Engl J Med, 1987, 316(7):379-385.
[14]How OJ, Aasum E, Severson DL, et al. Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice［J］. Diabetes, 2006, 55(2):466-473.
[15]Lebeche D, Davidoff AJ, Hajjar RJ. Interplay between impaired calcium regulation and insulin signaling abnormalities in diabetic cardiomyopathy［J］. Nat Clin Pract Cardiovasc Med, 2008, 5(11):715-724.
[16]Ren J, Pulakat L, Whaley-Connell A, et al. Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease［J］. J Mol Med (Berl), 2010, 88(10):993-1001.
[17]Tuunanen H, Knuuti J. Metabolic remodelling in human heart failure［J］. Cardiovasc Res, 2011, 90(2):251-257.
[18]Nagoshi T, Yoshimura M, Rosano GM, et al. Optimization of cardiac metabolism in heart failure［J］. Curr Pharm Des, 2011, 17(35):3846-3853.
[19]van de Weijer T, Schrauwen-Hinderling VB, Schrauwen P. Lipotoxicity in type 2 diabetic cardiomyopathy［J］. Cardiovasc Res, 2011, 92(1):10-18.
[20]Falcao-Pires I, Leite-Moreira AF. Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment[J].Heart Fail Rev,2012,17(3):325-344.
[21]Amato L,Paolisso G,Cacciatore F,et al.Congestive heart failure predicts the development of non-insulin-dependent diabetes mellitus in the elderly.The Osservatorio Geriatrico Regione Campania Group[J].Diabetes Metab,1997,23(3):213-218.
[22]Tenenbaum A,Motro M,Fisman EZ,et al.Functional class in patients with heart failure is associated with the development of diabetes[J].Am J Med,2003,114(4):271-275.
[23]Heck PM,Dutka DP.Insulin resistance and heart failure[J].Curr Heart Fail Rep,2009,6(2):89-94.
[24]Coats AJ,Anker SD.Insulin resistance in chronic heart failure[J].J Cardiovasc Pharmacol,2000,35(7 Suppl 4):S9-S14.
[25]Mamas MA,Deaton C,Rutter MK,et al.Impaired glucose tolerance and insulin resistance in heart failure:underrecognized and undertreated?[J].J Card Fail,2010,16(9):761-768.
[26]Putnam K,Shoemaker R,Yiannikouris F,et al.The renin-angiotensin system:a target of and contributor to dyslipidemias,altered glucose homeostasis,and hypertension of the metabolic syndrome[J].Am J Physiol Heart Circ Physiol,2012,302(6):H1219-H1230.
[27]Whaley-Connell A,Mccullough PA,Sowers JR.The role of oxidative stress in the metabolic syndrome[J].Rev Cardiovasc Med,2011,12(1):21-29.
[28]Lastra G,Dhuper S,Johnson MS,et al.Salt,aldosterone,and insulin resistance:impact on the cardiovascular system[J].Nat Rev Cardiol,2010,7(10):577-584.
[29]Kim JA,Wei Y,Sowers JR.Role of mitochondrial dysfunction in insulin resistance[J].Circ Res,2008,102(4):401-414.
[30]Dhand R,Hiles I,Panayotou G,et al.PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity[J].EMBO J,1994,13(3):522-533.

备注/Memo

备注/Memo:
收稿日期：2015-07-23.
基金项目：国家自然科学基金项目资助（81200174）
通讯作者：付锋，讲师，主要从事心肌保护研究 Email:fufeng048@126.com
作者简介：梁鹏，本科生 Email:2606463323@qq.com
更新日期/Last Update: 2016-01-07