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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2016年第3期

页码:

356-361

栏目:

综述

出版日期:

2016-01-05

文章信息/Info

Title:

Progress of application of Amplatzer occluders in transcatheter closure of perimembranous ventricular septal defect

作者:

王建铭¹; 2; 杨 剑³; 崔 斌²; 朱鲜阳¹

（1.沈阳军区总医院先心内科，辽宁 沈阳 110016；
2.解放军第201医院急诊科，辽宁 辽阳 111000；
3.第四军医大学西京医院心血管外科，陕西 西安 710032）

Author(s):

WANG Jian-ming¹; 2;  YANG Jian³;  CUI Bin²;  ZHU Xian-yang¹

(1.Department of Congenital Heart Disease, General Hospital, Shenyang Military Area Command, Shenyang 110016, Liaoning, China；
2.Department of Emergency, PLA 201 Hospital, Liaoyang,111000, Liaoning, China；
3.Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)

关键词:

Amplazter封堵器; 膜周部室缺; 完全性房室传导阻滞

Keywords:

Amplatzer occluder;  Perimembranous ventricular septal defects;  complete atrioventricular block

分类号:

R541.1

DOI:

-

文献标识码:

A

摘要:

膜周部室间隔缺损（室缺）是最常见的先天性心脏病。自从本世纪初Amplatzer膜周型封堵器被广泛应用于膜周部室缺介入封堵治疗。同时新型改良设计的Amplatzer封堵器陆续问世，以及多种Amplazter封堵器非常规应用于膜周部室缺封堵，并开展了大量的临床应用研究。目前由于应用初代Amplatzer膜周型封堵器后近期或远期完全性房室传导阻滞并发症发生率较高，许多中心放弃了对其继续研究应用。对于完全性房室阻滞的机制深入探究以及封堵器选择应用进一步优化，将使Amplatzer封堵器在临床中具有广泛的应用空间，并为膜周部室缺的介入封堵治疗提供了新的思路。

Abstract:

Perimembranous ventricular septal defects (pmVSDs) are the most common congenital heart disease. Since the early 2000 s, Amplatzer pmVSD occluder (AGA Medical, Golden Valley, MN, USA) has been widely used in transcatheter procedures for closure of pmVSDs. Recently, clinical trials with modified Amplatzer occluder and other new devices have demonstrated promising results in initial studies. Unfortunately, many medical centers have abandoned the first-generation Amplatzer pmVSD occluders due to their unacceptably high risk of postprocedural and late-onset complete atrioventricular block (cAVB). However, study of the mechanism of cAVB and further optimal selection of occluders will provide a new approach for application of Amplatzer occluders in transcatheter closure of pmVSDs.

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备注/Memo

备注/Memo:

收稿日期：2015-02-27.
基金项目：国家自然科学基金项目资助（81170213）
通讯作者：朱鲜阳，教授，主要从事结构性心脏病研究 Email:xyangz2011@163.com
作者简介：王建铭，博士生 Email:cyrusaaaa@hotmail.com

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更新日期/Last Update: 2016-01-07