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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2016年第4期

页码:

431-434,442

栏目:

临床研究

出版日期:

2016-04-01

文章信息/Info

Title:

Therapeutic effects of buyanghuanwu compound in patients with angina after coronary artery stenting

作者:

王玉珍¹; 王 博²; 李 飞²; 李伟杰²; 陶 凌²; 王 琼²; 刘海涛³

(第四军医大学：1.西京医院中医科，2.西京医院心血管内科，3.学员一旅，陕西 西安 710032)

Author(s):

WANG Yu-zhen¹;  WANG Bo²;  LI Fei²;  LI WEI-jie²;  TAO Ling²;  WANG Qiong²;  LIU Hai-tao³

(1.Department of Traditional Chinese Medicine, 2.Department of Cardiology, First Affiliated Hospital, 3.Cadet Brigade Fourth Military University, Xi’an 710032, Shaanxi, China)

关键词:

补阳还五汤; 冠脉支架术后; 心绞痛; 缺血心肌

Keywords:

buyanghuanwu compound;  angina;  postoperative coronary stenting;  ischemic myocardium

分类号:

R541.4

DOI:

-

文献标识码:

A

摘要:

目的 观察补阳还五汤对冠脉支架植入术后患者心绞痛的临床疗效。方法 随机纳入冠脉支架术后仍有心绞痛发作的患者，分为常规治疗组及加用补阳还五汤治疗组（试药组）。两组术后定期随访并调整基本治疗药物，观察心绞痛发作次数，行平板心电图检查观察心电图变化、测定两组治疗前后外周血一氧化氮（NO）、内皮素（ET）-1、超敏C反应蛋白（hs-CRP）及血管内皮生长因子（VEGF）水平；同时静息心肌核素显像观察缺血心肌面积变化。结果 试药组能显著减少冠脉支架术后心绞痛患者的心绞痛发作次数。平板心电图检查可见试药组在术后6个月时阴性率上升，阳性率下降，而常规治疗组则无显著差异。两组在术后1个月NO水平均显著上升，而ET-1及hs-CRP均显著下降，并且试药组变化更明显。治疗6个月后，试药组VEGF水平较治疗前明显上升，与常规治疗组比较亦有统计学差异。静息心肌核素扫描观察到两组术后6个月时缺血心肌的面积较术后即刻明显减小，且试药组较常规治疗组缺血心肌面积改善更显著。结论 补阳还五汤治疗冠脉支架术后心绞痛患者的疗效优于常规治疗。

Abstract:

AIM To observe the clinical curative effects of buyanghuanwu compound on patients with angina after coronary stenting. METHODSPostoperative patients with angina were randomized into two groups: routine medication team and buyanghuanwu compound team. All patients received regular follow-up and medications were adjusted as necessary. Frequency of angina attacks was recorded. ECG changes were detected by treadmill ECG examination. Levels of NO, ET-1, hs-CRP, and VEGF in peripheral blood were assayed. We also observed the area of ischemic myocardium using resting myocardial scintigraphy. RESULTSBuyanghuanwu compound significantly reduced frequency of angina attacks in postoperative patients with angina pectoris. At 6 postoperative months, treadmill ECG examination showed a significant increase in negative rate and decline in positive rate in the group administered buyanghuanwu compound, whereas the control group showed no significant differences. At 1 postoperative month, NO levels significantly increased and hs-CRP and ET-1 significantly decreased in two groups, but the changes were more obvious in the buyanghuanwu compound group. After 6 months treatment, VEGF level significantly increased compared to levels before treatment in the buyanghuanwu treatment group. Control group showed a significant difference. The results of resting myocardial scintigraphy showed that myocardial ischemic area was obviously decreased after a 6-month treatment with buyanghuanwu compound, whereas changes in the control group were not obvious. CONCLUSIONDecrease in the frequency of angina attacks in the buyanghuanwu compound group is superior to the group administered routine medication in coronary stent patients with angina pectoris.

参考文献/References

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备注/Memo

备注/Memo:

收稿日期：2015-09-08.
基金项目：陕西省中医管理局中医药科研课题资金资助(13-JC032)
通讯作者：刘海涛，主治医师，主要从事冠心病与先心病诊断与治疗的研究 Email：cardio@fmmu.edu.cn
作者简介：王玉珍，主治医师，硕士 Email：xjcardio@hotmail.com

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更新日期/Last Update: 2016-04-01