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Title:: Effect of fasudil on inflammatory factors in serum and gingival crevicular fluid in patients with coronary heart disease and periodontitis

作者:: 潘娜娜¹; 谭丽娟¹; 范春²; 宇仁超¹; 张蕊¹; 蔡尚郎¹; （青岛大学附属医院:1.心内科，2.口腔科，山东青岛 266555）

Author(s):: PAN Na-na¹; TAN Li-juan¹; FAN Chun²; YU Ren-chao¹; ZHANG Rui¹; CAI Shang-lang¹; (1.Department of Cardiology, 2.Department of Periodontics, Affiliated Hospital of Qingdao University, Qingdao 266555, Sandong, China)

关键词:: 冠状动脉疾病; 牙周炎; 炎性因子; 法舒地尔

Keywords:: coronary heart disease; periodontitis; inflammatory factor; fasudil

分类号:: R541.4

DOI:: -

文献标识码:: A

摘要:: 目的观察法舒地尔对冠心病并牙周炎患者血清及龈沟液中炎性因子白介素（IL）-10，IL-18的影响。方法住院的冠心病伴牙周炎的患者，随机分为2组：对照组及试药组，试药组在一般治疗的基础上给予法舒地尔30 mg加入生理盐水100 ml，静脉滴注，2次/d，治疗2周，在治疗前后行口腔检查，采集龈沟液及静脉血，应用ELISA法对患者龈沟液及血清中IL-10及IL-18进行测定。结果法舒地尔治疗后患者的血清及龈沟液中IL-18水平较对照组显著降低，IL-10水平显著升高(均P<0.05)。结论法舒地尔能够有效降低冠心病并牙周炎患者血清及龈沟液中炎性因子的水平。

Abstract:: AIM To explore the effect of fasudil on inflammatory cytokine interleukin 10 (IL-10) and interleukin-18 (IL-18) in serum and gingival crevicular liquid in patients with coronary heart disease (CHD) and periodontitis. METHODSWe selected hospitalized patients with CHD and periodontitis and randomly divided the patients into two groups: treatment group and control group. The treatment group was given intravenous drip of fasudil (30 mg bid) in addition to the routine treatment for 2 weeks. Before and after treatment, we examined the oral cavity and collected the gingival crevicular fluid and venous blood. IL-10 and IL-18 in gingival crevicular fluid and serum in both groups were analyzed using enzyme-linked immunosorbent assay. RESULTSAfter fasudil treatment, IL-18 levels in the gingival fluid and serum of patients in the treatment group significantly decreased and IL-10 levels were significantly increased (P<0.05) compared with those in the control group. CONCLUSION Fasudil can effectively reduce the level of inflammatory factors in the gingival fluid and serum of patients with coronary heart disease and periodontitis.

参考文献/References

[1]Nakajima T,Yamazaki K.Periodontal disease and risk of atherosclerotic coronary heart disease[J].Odontology,2009,97(2):84-91.
[2]Johansson CS,Ravald N,Pagonis C,et al.Periodontitis in patients with coronary artery disease: an 8-year follow-up[J].J Periodontol,2014,85(3):417-425.
[3]马建英,谭丽娟,潘娜娜.法舒地尔对急性心肌梗死大鼠炎性细胞因子表达的影响[J].临床心血管病杂志,2011,27(4):313-315.
[4]叶欣,杨丕山.冠心病与牙周炎间的临床和生物学相关性研究[J].国际口腔医学杂志,2013,40(3):323-325.
[5]Zhu H,Lin X,Zheng P,et al.Inflammatory cytokine levels in patients with periodontitis and/or coronary heart disease[J].Int J Clin Exp Pathol,2015,8(2):2214-2220.
[6]Humphrey LL,Fu R,Buckley DI,et al.Periodontal disease and coronary heart disease incidence: A systematic review and meta-analysis[J].J Gen Intern Med,2008,23(12)：2079-2086.
[7]胡章乐,马礼坤.白介素-18与急性冠状动脉综合征[J].国际病理科学与临床杂志,2007,27(1):57-59.
[8]王龙飞,谈敏.白介素10与动脉粥样硬化的研究现状［J］. 国外医学·老年医学分册, 2008, 29(3):128-131.
[9]Wettschureck N, Offermanns S.Rho/Rho- kinase mediated signaling inphysiology and pathophysiology[J].J Mol Med,2002,80(16):629-638.
[10]Tzorbatzoglou ID,Sfyroeras GS, Giannoukas AD.Periodontitis and carotid atheroma:is there a causal relationship?[J].Int Angiol,2010,29(1):27-29.

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法舒地尔对冠心病并牙周炎患者血清及龈沟液中炎性因子的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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