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Title:: Relationship between blood pressure circadian rhythm and monocyte chemattractant-1, intercellular adhesion molecule-1 and homocysteine in elderly hypertensive patients

作者:: 于秀珍¹; 张艳敏¹; 刘永²; ( 新疆维吾尔自治区人民医院：1.医务部，2.心内科，新疆乌鲁木齐 830001)

Author(s):: YU Xiu-zhen¹; ZHANG Yan-min¹; LIU Yong²; (1.Department of Medicine, 2.Department of Cardiology, People’s Hospital, Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang, China)

关键词:: 原发性高血压; 老年; 血清单核细胞趋化蛋白-1; 细胞间黏附分子-1; 同型半胱氨酸

Keywords:: elderly patients; hypertension; monocyte chemattractant-1; intercellular adhesion molecule-1; homocysteine

分类号:: R544.1

DOI:: -

文献标识码:: A

摘要:: 目的分析老年高血压病患者血压昼夜节律与单核细胞趋化蛋白（MCP）-1、细胞间黏附分子(sICAM)-1和同型半胱氨酸(Hcy)的相关性。方法选入我院住院确诊的老年原发性高血压患者172例，所有病例均进行24 h无创动态血压监测，根据患者血压昼夜节律变化，将患者分为杓型组（n=55）、非杓型组(n=71)和反杓型组(n=46)。检测患者的血清MCP-1、sICAM-1和Hcy的含量。结果杓型组、非杓型组和反杓型组MCP-1、sICAM-1和Hcy水平依次升高〔分别为(27±13)ng/L、(32±14)ng/L和(37±12)ng/L;(2433±745)ng/L、(2726±573)ng/L和(2862±514)ng/L；(16±8)mmol/L、(19.15±8.4)mmol/L和(22±10)mmol/L，均P<0.05〕；多元逐步线性回归显示MCP-1、sICAM-1和Hcy为患者血压节律改变的影响因素，偏回归系数分别为-0.001、-2.1×10-5、-0.002。结论 MCP-1、sICAM-1、Hcy为老年高血压病患者血压昼夜节律改变的相关因素。

Abstract:: AIM To explore the relationship between blood pressure circadian rhythm and monocyte chemoattractant-1, intercellular adhesion molecule-1 and homocysteine in elderly hypertensive patients. METHODSA total of 172 patients with elderly primary hypertension undergoing 24-h ambulatory blood pressure monitoring were included in this study and divided into three groups: dipper group (n=55), non-dipper group (n=71) and reverse dipper group (n=46). Monocyte chemattractant-1 (MCP-1), intercellular adhesion molecule-1 (sICAM-1) and homocysteine (HCY) were detected in all patients. RESULTSThe levels of MCP-1, sICAM-1 and HCY increased, respectively, in all three groups ［(27±13) ng/L, (32±14) ng/L and (37±12) ng/L; (2433±745) ng/L, (2726±573) ng/L and (2862±514) ng/L; (16±8) mmol/L, (19.15±8.4) mmol/L and (22±10) mmol/L; all P<0.05］. Stepwise multivariate linear regression showed that MCP-1, HCY and sICAM-1 may be the influencing factors of blood pressure circadian rhythm (partial regression coefficient (B): -0.001, -2.1×10-5 and -0.002, respectively). CONCLUSIONMCP-1, sICAM-1 and HCY may be the influencing factors of blood pressure circadian rhythm in elderly hypertensive patients.

参考文献/References

[1]马庆春.关注血压节律,平稳降压,保护靶器官[J].中国心血管杂志,2008,6(13):165-166.
[2]中华医学会老年医学分会,中国医师协会高血压专业委员会.老年人高血压特点与临床诊治流程专家建议[J].中华老年医学杂志,2014,7(33):689-701.
[3]中国高血压指南修订委员会.中国高血压防止指南2010[J].中国高血压杂志,2011,8(19):701-743.
[4] Shalia KK,Shah VK,Mashru MR,et al.Circulating levels of cell adhesion molecules in hypertension[J].Indian J Clin Biochem,2009,24(4):388-397.
[5]Wang L,Manson JE,Gaziano JM,et al.Circulating Inflammatory and Endothelial Markers and Risk ofHypertension in White and Black Postmenopausal Women[J].Clin Chem,2011,57(5):729-7361.
[6]Khaleghi M,Ali Z,Mosley TH Jr,et al.Association of soluble cell adhesion molecules with ankle-brachial index in a biethnic cohort of predominantly hypertensive individuals[J].Clin Chem,2008,54(11):1788-1795.
[7]刘泽军,李晚珍,吴礼文.原发性高血压患者血压昼夜节律与细胞因子的相关性研究[J].中国医药指南,2013,11(23):2-3.
[8]Deng B,Fang F,Yang T,et al.Ghrelin inhibits AngIIinduced expression of TNF-α,IL-8,MCP-1 in human umbilical vein endothelial cells[J].Int J Clin Exp Med,2015,8(1):579-588.
[9]Sen U,Tyagi SC.Homocysteine and Hypertension in Diabetes:Does PPARγ Have a Regulatory Role? [J].PPAR Res,2010,2010:806538.
[10]龙静,宓宝斌,张清潭,等.不同类型老年高血压患者血浆同型半胱氨酸变化与动脉硬化的关系[J].中华老年心脑血管病杂志,2013,3(15):241-243.
[11]Abraham JM,Cho L.The homocysteine hypothesis:still relevant to the prevention and treatment of cardiovascular disease?[J].Cleve Clin J Med,2010,77(12):911-918.
[12]徐艳芳,任澎.心血管疾病危险因素研究新进展[J].心血管康复医学杂志,2015,2(24):98-101.
[13]陈震,蒋益波,孙欣,等.非杓型血压的临床特点及相关因素分析[J].心脏杂志,2014,26(2):154-156.

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老年高血压病患者血压昼夜节律与MCP-1、sICAM-1和Hcy的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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