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|本期目录/Table of Contents|

钠钙交换体1参与窦房结细胞起搏活动研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第5期
页码:
585-588
栏目:
综述
出版日期:
2016-04-25

文章信息/Info

Title:
Research progress of sodium calcium exchanger 1 in pacemaker activation of sinus node cells
作者:
汪艳丽; 刘如秀; 刘金凤
（中国中医科学院广安门医院心内科，北京 100053）
Author(s):
WANG Yan-li;  LIU Ru-xiu;  LIU Jin-feng
(Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China)
关键词:
钠钙交换体1; 窦房结细胞; 起搏
Keywords:
sodium calcium exchanger 1;  sino-atrial node cells;  pacemaker
分类号:
R541.7
DOI:
-
文献标识码:
A
摘要:
窦房结细胞是窦房结起搏活动的基础，维持着心脏的正常活动。病态窦房结综合征是常见心血管重大疑难疾病之一，由窦房结起搏及（或）传导功能障碍所致，归因于窦房结起搏细胞的自发性动作电位异常，钠钙交换体1在窦房结细胞动作电位的产生和维持过程中具有重要作用，其功能异常，可导致窦房结起搏功能障碍而引发病态窦房结综合征。
Abstract:
Sino-atrial node cells (SNCs) are the basis of sinus node pacemaker activity, maintaining normal cardiac activity. Sick sinus syndrome (SSS) is one of the most common cardiovascular diseases, mainly resulting from sinus pacing and/or conduction disorders caused by sinus node dysfunction due to the spontaneous action potential abnormalities of sinus node pacemaker cells. Sodium calcium exchanger 1 (NCX1) plays an important role in SNCs action potentials generation and maintenance process, the dysfunction of which can lead to sinus node dysfunction resulting in SSS.

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备注/Memo

备注/Memo:
收稿日期：2015-05-03.
基金项目：国家自然科学基金项目资助（81173447）
通讯作者：刘如秀，主任医师，主要从事心血管疾病中西医结合防治研究 Email：liuruxiu1@yahoo.com.cn
作者简介：汪艳丽，主治医师 Email：15201551034@163.com
更新日期/Last Update: 2016-04-13