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|本期目录/Table of Contents|

大电导钙激活钾通道在高血压病中的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第5期
页码:
589-592,600
栏目:
综述
出版日期:
2016-04-25

文章信息/Info

Title:
Research progress of large conductance Ca2+-activated K+ channel in hypertension
作者:
曹乾嫱1; 付幼林2; 王云霞3; 张淑华3; 罗 骏2
（1.江西省人民医院心内一科，江西 南昌 330000；
2.赣州市人民医院心内科，江西 赣州 341000；
3.江西省人民医院、江西省心血管病研究所，江西 南昌 330000；
）
Author(s):
CAO Qian-qiang1;  FU You-lin2;  WANG Yun-xia3;  ZHANG Shu-hua3;  LUO Jun2
(1.Department of Cardiology, Jiangxi Province People’s Hospital, Nanchang 330000, Jiangxi, China；
2.Department of Cardiology, Ganzhou People’s Hospital, Ganzhou 341000, Jiangxi, China；
3.Jiangxi Provincial Research Institute for Cardiovascular Disease, Nanchang 330000, Jiangxi, China)
关键词:
高血压; 血管平滑肌细胞; 离子通道; 大电导钙激活钾通道
Keywords:
hypertension;  vascular smooth muscle cell;  ion channel;  BKCa channel
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
大电导钙激活钾通道（BKCa）是血管平滑肌细胞（VSMCs）上表达最丰富的钾通道，对维持VSMCs的膜电位及血管收缩和舒张的动态平衡具有重要的调节作用。BKCa通道的激活可使细胞膜发生超极化，从而抑制电压依赖性钙通道的激活和钙离子内流，导致平滑肌舒张。对高血压患者的观察和高血压动物模型的研究发现，高血压血管张力升高时平滑肌细胞膜表面钾离子和钙离子通道表达和功能均发生异常，因此，有人推测高血压是离子通道重构导致平滑肌细胞去极化的结果。本文主要综述近年来BKCa通道在高血压病中的研究进展。
Abstract:
Large conductance Ca2+-activated K+ (BKCa) channels are abundantly expressed in vascular smooth muscle cells (VSMCs). Activation of BKCa channels leads to hyperpolarization of the plasma membrane, closure of Ca2+ channels, reduced intracellular Ca2+ levels and eventually vasodilation. Therefore, BKCa channels play an important role in determining membrane potential and regulation of vascular tone. The elevated vascular tone observed in human hypertension and in several experimental models of hypertension points to abnormalities of the expression and function of Ca2+ and/or K+ channels in VSMCs. VSMCs are more depolarized as a consequence of the ‘ion channel remodeling’ that occurs during chronic hypertension. In this review, we will mainly focus on BKCa channels in VSMCs that are reported to be altered in hypertension.

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备注/Memo

备注/Memo:
收稿日期: 2015-04-09.
基金项目：国家自然科学基金项目资助（81260065）；江西省自然科学基金项目资助（2013BAB205035）
通讯作者：罗骏，主任医师，主要从事冠心病和心律失常基础与临床研究 Email:luojun1966@medmail.com.cn
作者简介：曹乾嫱，主治医师 Email:cqianqiang@163.com
更新日期/Last Update: 2016-04-13