文章摘要

文章信息/Info

Title:: Research progress in relationship between melatonin and cardiovascular diseases

作者:: 杨金保综述; 陈文生审校; （第四军医大学西京医院心血管外科，陕西西安 710032）

Author(s):: YANG Jin-bao; CHEN Wen-sheng; (Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)

关键词:: 褪黑素; 心血管疾病; 缺血/再灌注损伤; 高血压

Keywords:: melatonin; cardiovascular disease; myocardial ischemia reperfusion injury; hypertension

分类号:: R54

DOI:: -

文献标识码:: A

摘要:: 褪黑素是一种主要由松果体合成的激素。它的合成和分泌受到光强度的调节，并且其分泌量随着年龄的增长而逐渐减少。研究发现，褪黑素有调节睡眠周期、抗氧化和抗炎、调节脂质和葡萄糖代谢的功能。近年有研究表明，褪黑素在高血压、心肌缺血/再灌注损伤（MI/RI）、肺动脉高压、心肌慢性间歇性低氧损伤、血管疾病以及心脏瓣膜疾病等多种心血管疾病中起着重要作用。本文就褪黑素与心血管疾病关系的研究进展做一简要阐述。

Abstract:: Melatonin is a neuroendocrine hormone, which is synthesized primarily by the pineal gland. The synthesis and secretion of melatonin are regulated by light intensity. It has been found that melatonin has functions in regulating the sleep cycle, antioxidant and anti-inflammatory. Melatonin has also been shown to regulate lipid and glucose metabolism. Recent research suggests that melatonin plays an important role in various cardiovascular diseases, including hypertension, myocardial ischemia-reperfusion injury, pulmonary hypertension, myocardial chronic intermittent hypoxic injury, vascular diseases and valvular heart diseases. In this paper, the relationship between melatonin and cardiovascular diseases is described.

参考文献/References

[1]Yu L,Liang H,Lu Z,et al.Membrane receptor-dependent Notch1/Hes1 activation by melatonin protects against myocardial-ischemia reperfusion injury:in vivo and in vitro studies[J].J Pineal Res,2015,59(4):420-433.
[2]Ghaeli P,Vejdani S,Ariamanesh A,et al.Effect of melatonin on cardiac injury after primary percutaneous coronary intervention:a randomized controlled trial[J].Iran J Pharm Res,2015,14(3):851-855.
[3]Yu L,Sun Y,Cheng L,et al.Melatonin receptor-mediated protection against myocardial ischemia/reperfusion injury:role of SIRT1[J].J Pineal Res,2014,57(2):228-238.
[4]Han D,Huang W,Li X,et al.Melatonin facilitates adipose-derived mesenchymal stem cells to repair the murine infarcted heart via the SIRT1 signaling pathway[J].J Pineal Res,2016,60(2):178-192.
[5]Zhu P,Liu J,Shi J,et al.Melatonin protects ADSCs from ROS and enhances their therapeutic potency in a rat model of myocardial infarction[J].J Cell Mol Med,2015,19(9):2232-2243.
[6]Liu LF,Qin Q,Qian ZH,et al.Protective effects of melatonin on ischemia-reperfusion induced myocardial damage and hemodynamic recovery in rats[J].Eur Rev Med Pharmacol Sci,2014,18(23):3681-3686.
[7]Liu LF,Qian ZH,Qin Q,et al.Effect of melatonin on oncosis of myocardial cells in the myocardial ischemia/reperfusion injury rat and the role of the mitochondrial permeability transition pore[J].Genet Mol Res,2015,14(3):7481-7489.
[8]Yu L,Liang H,Dong X,et al.Reduced SIRT1 signaling exacerbates myocardial ischemia reperfusion injury in type 2 diabetic rats and the protective effect of melatonin[J].J Pineal Res,2015,59(3):376-390.
[9]Nduhirabandi F,Lamont K,Albertyn Z,et al.Role of toll-like receptor4 in melatonin-induced cardioprotection[J].J Pineal Res,2016,60(1):39-47.
[10]Borghi C,Cicero AF.Nutraceuticals with clinically detectable blood pressure lowering effect:a review of available randomized clinical trials and their meta-analyses[J].Br J Clin Pharmacol,2017,83(1):163-171.
[11]Simko F,Pechanova O,Repova Bednarova K,et al.Hypertension and cardiovascular remodelling in rats exposed to continuous light:protection by ACE-inhibition and melatonin[J].Mediators Inflamm,2014,2014:703175.
[12]Gubin DG,Gubin GD,Gapon LI,et al.Daily melatonin administration attenuates age-dependent disturbances of cardiovascular rhythms[J].Curr Aging Sci,2016,9(1):5-13.
[13]Sewerynek E.Melatonin and the cardiovascular system[J].Neuroendocrinol Lett,2002,23(1):79-83.
[14]Ilhan S,Atessahin D,Atessahin A,et al.2,3,7,8-Tetrachlorodibenzo-p-dioxininduced hypertension:the beneficial effects of melatonin[J].Toxicol Ind Health,2015,31(4):298-303.
[15]Rexhaj E,Pireva A,Paoloni-Giacobino A,et al.Prevention of vascular dysfunction and arterial hypertension in mice generated by assisted reproductive technologies by addition of melatonin to culture media[J].Am J Physiol Heart Circ Physiol,2015,309(7):H1151-H1156.
[16]Yeung HM,Hung MW,Lau CF,et al.Cardioprotective effects of melatonin against myocardial injuries induced by chronic intermittent hypoxia in rats[J].J Pineal Res,2015,58(1):12-25.
[17]Xie S,Deng Y,Pan YY,et al.Melatonin protects against chronic intermittent hypoxia-induced cardiac hypertrophy by modulating autophagy through the 5’adenosine monophosphate-activated protein kinase pathway[J].Biochem Biophys Res Commun,2015,464:975-981.
[18]Yu J,Wei J,Ji L,et al.Exploration on mechanism of a new type of melatonin receptor agonist Neu-p11 in hypoxia-reoxygenation injury of myocardial cells[J].Cell Biochem Biophys,2014,70(2):999-1003.
[19]Ortiz F,Garcia JA,Acuna-Castroviejo D,et al.The beneficial effects of melatonin against heart mitochondrial impairment during sepsis:inhibition of iNOS and preservation of nNOS[J].J Pineal Res,2014,56(1):71-81.
[20]Maarman G,Blackhurst D,Thienemann F,et al.Melatonin as a preventive and curative therapy against pulmonary hypertension[J].J Pineal Res,2015,59(3):343-353.
[21]Torres F,Gonzalez-Candia A,Montt C,et al.Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep[J].J Pineal Res,2015,58(3):362-373.
[22]Jin H,Wang Y,Zhou L,et al.Melatonin attenuates hypoxic pulmonary hypertension by inhibiting the inflammation and the proliferation of pulmonary arterial smooth muscle cells[J].J Pineal Res,2014,57(4):442-450.
[23]Cheng X,Wan Y,Xu Y,et al.Melatonin alleviates myosin light chain kinase expression and activity via the mitogen-activated protein kinase pathway during atherosclerosis in rabbits[J].Mol Med Rep,2015,11(1):99-104.
[24]Tang ST,Su H,Zhang Q,et al.Melatonin attenuates aortic endothelial permeability and arteriosclerosis in streptozotocin-induced diabetic rats:possible role of MLCK- and MLCP-dependent MLC phosphorylation[J].J Cardiovasc Pharmacol Ther,2016,21(1):82-92.
[25]Zhu HQ,Li Q,Dong LY,et al.MicroRNA-29b promotes high-fat dietstimulated endothelial permeability and apoptosis in apoE knock-out mice by down-regulating MT1 expression[J].Int J Cardiol,2014,176(3):764-770.
[26]Tang ST,Su H,Zhang Q,et al.Melatonin attenuates aortic endothelial permeability and arteriosclerosis in streptozotocin-induced diabetic rats:possible role of MLCK- and MLCP-dependent MLC phosphorylation[J].J Cardiovasc Pharmacol Ther,2016,21(1):82-92.
[27]Yang GH,Li YC,Wang ZQ,et al.Protective effect of melatonin on cigarette smoke-induced restenosis in rat carotid arteries after balloon injury[J].J Pineal Res,2014,57(4):451-458.
[28]Salmanoglu DS,Gurpinar T,Vural K,et al.Melatonin and L-carnitin improves endothelial disfunction and oxidative stress in Type 2 diabetic rats[J].Redox Biol,2016,8:199-204.
[29]Yang Y,Fan C,Deng C,et al.Melatonin reverses flow shear stress-induced injury in bone marrow mesenchymal stem cells via activation of AMP-activated protein kinase signaling[J].J Pineal Res,2016,60(2):228-241.
[30]Sun H,Huang FF,Qu S.Melatonin:a potential intervention for hepatic steatosis[J].Lipids Health Dis,2015,14:75.
[31]Celinski K,Konturek PC,Slomka M,et al.Effects of treatment with melatonin and tryptophan on liver enzymes, parameters of fat metabolism and plasma levels of cytokines in patients with nonalcoholic fatty liver disease-14 months follow up[J].J Physiol Pharmacol,2014,65(1):75-82.
[32]Wang Z,Ni L,Wang J,et al.The protective effect of melatonin on smokeinduced vascular injury in rats and humans:a randomized controlled trial[J].J Pineal Res,2016,60(2):217-227.
[33]Allagui MS,Hachani R,Saidi S,et al.Pleiotropic protective roles of melatonin against aluminium-induced toxicity in rats[J].Gen Physiol Biophys,2015,34(4):415-424.

我们的网站为什么显示成这样？

褪黑素与心血管疾病关系的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

文章信息/Info

参考文献/References

备注/Memo

常用功能

导航/Navigate

工具/Tools

统计/Statistics