LOX-1在动脉粥样硬化中的作用研究新进展
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2018年第2期
- 页码:
- 212-217
- 栏目:
- 综述
- 出版日期:
- 2018-02-15
文章信息/Info
- Title:
- Effect of LOX-1 on development of atherosclerosis
- Author(s):
- ZHENG Xu1; ZHENG Meng-ke2; DENG Jiao3; DONG Hai-long3
- (1.Cadet Brigade, 2.Nursing Department, 3.Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
- 关键词:
- 瘦素样氧化型低密度脂蛋白受体1; 氧化型低密度脂蛋白; 动脉粥样硬化
- 分类号:
- R543.5
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 动脉粥样硬化(AS)是一种血管慢性炎症性病变，其中内皮细胞功能异常、单核细胞的黏附和迁移、平滑肌细胞的凋亡、泡沫细胞的形成和血小板的活化是AS形成的关键环节，最终结果是形成大、中动脉内膜下的粥样硬化斑块，造成管腔狭窄，远端组织器官供血不足甚至栓塞。低密度脂蛋白（LDL） 氧化形成的氧化型LDL（ox-LDL）在AS发生、发展过程中起着重要作用。目前在与AS发生、发展相关的细胞（如血管内皮细胞、血管平滑肌细胞、单核细胞、巨噬细胞以及泡沫细胞）上已经发现和鉴定了多种oxLDL受体，其中瘦素样氧化型低密度脂蛋白受体(LOX)-1表达于血管内皮细胞、巨噬细胞、血小板上，是ox-LDL的主要受体［1］，在AS的发生、发展中起着重要作用，本文将着重阐述近年来LOX-1影响AS发生发展相关效应与机制的新进展。
- Abstract:
- Atherosclerosis (AS) is a chronic inflammation of blood vessels, in which endothelial cell dysfunction, monocyte adhesion and migration, apoptosis of smooth muscle cell, foam cell formation, and platelet activation are all critical parts of atherosclerosis. AS will result in large and medium artery atherosclerotic plaques under the intima. Ox-LDL, which results from oxidation of low density lipoprotein (LDL), is involved in the occurrence and development of atherosclerosis. Many ox-LDL receptors have been found and identified on cells related to development of AS, such as vascular endothelial cells, vascular smooth muscle cells, monocytes, macrophages and foam cells. Lectin-like oxidized LDL receptor-1 (LOX-1), the main receptor of ox-LDL, is expressed on vascular endothelial cells, macrophages and platelets, and it plays a significant role in the development and progress of atherosclerosis. In this review, there is a focus on the latest development of effects of LOX-1 on AS development and related underlying mechanisms.
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备注/Memo
- 备注/Memo:
- 收稿日期: 2016-11-23.基金项目：国家自然科学基金项目资助(81300984) 通讯作者：董海龙，教授，主要从事围术期心脑保护机制研究 Email:hldong6@hotmail.com 作者简介：郑旭，本科生 Email:3052012043@student.fmmu.edu.cn 共同第一作者：张梦诃，本科生 Email:3452013010@stndent.fmmu.edu.cn
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