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|本期目录/Table of Contents|

转录因子FoxO1的修饰调节效应及在心血管疾病中的作用

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第2期
页码:
218-221
栏目:
综述
出版日期:
2018-02-15

文章信息/Info

Title:
Progress of transcription factor FoxO1 and its role in cardiovascular diseases
作者:
刘振华1; 王 珂1; 王馨佩1; 丁铭格2 ; 付 锋3
（第四军医大学：1.学员旅，3.生理学教研室，陕西 西安 710032；2.西安市中心医院老年病科，陕西 西安 710003）
Author(s):
LIU Zhen-hua1;  WANG Ke1;  WANG Xin-pei1;  DING Ming-ge2;  FU Feng3
(1.Cadet Brigade, 3.Department of Physiology, Fourth Military Medical University, Xi’an 710032, Shaanxi, China; 2.Department of Geriatrics, Xi’an Central Hospital, Xi’an 710003, Shaanxi, China)
关键词:
FoxO1; 转录因子; 翻译后修饰; 心血管疾病
Keywords:
transcription factor;  posttranslational modification;  cardiovascular diseases
分类号:
R392.11
DOI:
-
文献标识码:
A
摘要:
FoxO1是FoxO亚家族中最早发现的转录因子，其转录活性受到多种蛋白修饰的调节。近年研究显示，FoxO1在多种心血管疾病的发生、发展中都发挥着重要作用。本文在此对FoxO1的修饰调节效应及其在心血管疾病中的作用作一综述。
Abstract:
FoxO1 is the first transcription factor found in FoxO subfamily. The transcriptional activity of FoxO1 is regulated by a variety of protein modifications. Recent studies have shown that FoxO1 plays an important role in the development of cardiovascular diseases. In this article, a review is presented of posttranslational modification effects on FoxO1 and its role in cardiovascular diseases.

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备注/Memo

备注/Memo:
收稿日期：2017-02-15.基金项目：国家自然科学基金项目资助（81670354，81600235） 通讯作者：付锋，讲师，博士，主要从事心肌保护研究 Email:fufeng048@126.com 共同通讯作者：丁铭格，主治医师，博士，主要从事糖尿病心肌病研究 Email:435411499@qq.com 作者简介：刘振华，本科生 Email:945701553@qq.com
更新日期/Last Update: 1900-01-01