我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

生物可完全降解封堵器封堵犬卵圆孔未闭的实验研究

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第3期
页码:
270-273
栏目:
基础研究
出版日期:
2018-03-25

文章信息/Info

Title:
Animal experimental study of the fully biodegradable patant foramen ovale (PFO) occluder
作者:
谢 航; 杨 濛; 成革胜; 张婷婷; 杜亚娟; 何 璐; 张玉顺
（西安交通大学第一附属医院结构性心脏病科，陕西 西安 710061）
Author(s):
XIE Hang;  YANG Meng;  CHENG Ge-sheng;  ZHANG Ting-ting;  DU Ya-juan;  HE Lu;  ZHANG Yu-shun
(Department of Structural Heart Disease, First Affiliated Hospital, Xi'an Jiaotong University, Xi’an 710061, Shaanxi, China)
关键词:
封堵器; 生物可降解; 卵圆孔未闭; 犬
Keywords:
occluder;  fully biodegradable;  patent foramen ovale;  canine
分类号:
R541.1
DOI:
-
文献标识码:
A
摘要:
目的 评估生物可完全降解卵圆孔未闭（patent foramen ovale，PFO）封堵器封堵犬PFO的可行性、安全性等。方法 右胸小切口开胸卵圆窝穿刺法建立犬PFO模型，即刻在直视及经胸超声心动图（TTE）引导下用生物可完全降解型PFO封堵器封堵PFO。在植入后分别于1、3、6、9和12个月各处死2只犬，进行肉眼和组织学检查。结果 10只犬成功建立PFO模型后并植入可完全降解PFO封堵器。随访见封堵器均未发生移位，表面无赘生物及血栓形成，大体解剖见内膜组织从边缘逐渐完全覆盖封堵器表面。组织病理学提示，术后6个月封堵器骨架几乎完全降解并和周围组织融为一体。结论 应用生物可完全降解PFO封堵器封堵犬PFO，降解后在体内无任何残留物，是一种安全、有效并且可行的封堵器。
Abstract:
AIM To evaluate the feasibility, safety of a fully biodegradable occluder for closure of patent foramen ovale (PFO) in an acute canine model. METHODS The PFO was created in healthy canine by a homemade PFO perforator and the PFO was closed immediately by the fully biodegradable PFO occluder. Animals were sacrificed at 1, 3, 6, 9 and 12 months after procedure. RESULTS Acute PFO models were successfully created in 10 dogs and occluders was successfully implanted in the PFO model. The cardiac gross anatomy revealed that all occluders were stable in the fossa ovale and no vegetation or thrombosis formation was observed on the surface of all occluders. The endothelial tissue gradually covered from the edge of the surface of occluder. Different periods of pathological observations suggested that the skeleton of occluder is almost completely degraded and integrated with the host tissue at 6 month follow-up. CONCLUSION The present investigation applied fully biodegradable occluder to close PFO in a canine model and no residue was identified in the body after degradation.This is a safe, effective and feasible method of closing the PFO and the efficacy was similar when compared to a metal occluder.

参考文献/References

[1]Saver JL,Carroll JD,Thaler DE,et al.Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke[J].N Engl J Med,2017,377(11):1022-1032.

[2]Belgrave K,Cardozo S.Thrombus formation on amplatzer septal occluder device:pinning down the cause[J].Case Rep Cardiol,2014,2014:457850.

[3]Anzai H1,Child J,Natterson B,et al.Incidence of thrombus formation on the CardioSEAL and the Amplatzer interatrial closure devices[J].Am J Cardiol,2004,93(4):426-431.

[4]Hsu CW,Olabisi RM,Olmsted-Davis EA,et al.Cathepsin K-sensitive poly(ethylene glycol) hydrogels for degradation in response to bone resorption[J].J Biomed Mater Res A,2011,98(1):53-62.

[5]McBane JE,Sharifpoor S,Cai K,et al.Biodegradation and in vivo biocompatibility of a degradable,polar/hydrophobic/ionic polyurethane for tissue engineering applications[J].Biomaterials,2011,32(26):6034-6044.

[6]Sharafuddin MJ,Gu X,Titus JL,et al.Transvenous closure of secundum atrial septal defects:preliminary results with a new self-expanding nitinol prosthesis in a swine model[J].Circulation,1997,95(8):2162-2168.

[7]Jiang L,Zhang J.Biodegradable and Biobased Polymers-AppliedPlastics Engineering Handbook-9[M].USA:William Andrew Publishing,2011:145-158.

[8]Serruys PW,Ormiston JA,Onuma Y,et al.A bioabsorbable everolimus-eluting coronary stent system (ABSORB):2-year outcomes and results from multiple imaging methods[J].Lancet,2009,373(9667):897-910.

[9]Lischke R,Poznizk J,Vondrys D,et al.Novel biodegradable stents in the treat-ment of bronchial stenosis after lung transplantation[J].Eur J Cardiothorac Surg,2011,40(3):619-624.

[10]Zilberman M,Nelson KD,Eberhart RC. Mechanical properties and in vitro degra-dation of bioresorbable fibers and expandable fiber-based stents[J].J Biomed Mater Res B Appl Biomater,2005,74(2):792-799.

[11]Happel CM,Laser KT,Sigler M,et al.Single center experience:Implantation failures, early,and late complications after implantation of a partially biodegradable ASD/PFO-device(BioStar(R))[J].Catheter Cardiovasc Interv,2015,85(6):990-997.

备注/Memo

备注/Memo:
收稿日期：2017-06-23.基金项目：陕西省科技统筹创新工程计划项目资助（2014KTCL03-11） 通讯作者：张玉顺，主任医师，主要从事先天性心脏病介入治疗研究 Email：zys2889@sina.com 作者简介：谢航，硕士生 Email：472588806@qq.com
更新日期/Last Update: 1900-01-01