我们的网站为什么显示成这样?

可能因为您的浏览器不支持样式,您可以更新您的浏览器到最新版本,以获取对此功能的支持,访问下面的网站,获取关于浏览器的信息:

|本期目录/Table of Contents|

维吾尔族与汉族老年急性冠脉综合征患者的临床特征、冠脉病变特点以及危险因素分析

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第3期
页码:
278-281,288
栏目:
临床研究
出版日期:
2018-03-25

文章信息/Info

Title:
The clinical study of coronary artery lesion characteristic, clinical feature and risk factor in Uygur and Han elderly patients with acute coronary syndrome
作者:
依力哈木·阿不力提甫1古孜丽2李国庆2穆叶赛·尼加提12
(1.新疆医科大学研究生学院,2.新疆维吾尔自治区人民医院心内科,新疆 乌鲁木齐 830000)
Author(s):
Yilihamu·Abulitifu1 GU zi-li2 LI Guo-qing2 Muyesai·Nijiati12
(1.Graduate School, Xinjiang Medical University, Urumqi 830000, Xinjiang, China; 2.Department of Cardiology, People’s Hospital of Xinjiang Uygur Autonomous Region , Urumqi 830000, Xinjiang, China)
关键词:
维吾尔族汉族老年急性冠脉综合征冠状动脉病变特点危险因素
Keywords:
uygur and han elderly acute coronary syndrome characteristics of coronary artery lesions risk factors
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨维吾尔族与汉族老年急性冠脉综合征(ACS)患者的临床特征和冠状动脉病变特点以及维吾尔族老年ACS冠脉C型病变的危险因素。方法 回顾性分析330例在我院诊断考虑ACS并行冠脉造影的年龄≥65岁的维吾尔族与汉族患者临床资料、脂蛋白(Lp)α、血清尿酸(UA)、胱抑素(Cystatin,Cys)C、视黄醇结合蛋白(retinol binding protein,RBP)4、纤维蛋白原(FG)等生化指标。根据冠状动脉造影结果冠状动脉病变特点由冠状动脉血管优势分型、病变血管支数、病变累及血管、血管病变分型、Gensini积分表示。根据民族分为维吾尔族老年ACS组(154例)和汉族老年ACS组(176例)。根据冠脉造影结果将维吾尔族老年ACS患者分为冠状动脉C型病变组(99例)与冠状动脉非C型病变组(55例),分析影响维吾尔族冠状动脉C型病变的危险因素。结果 维吾尔族老年ACS组冠状动脉C型病变比例、Gensini积分明显高于汉族老年ACS组,差异有统计学意义(P<0.05)。维吾尔族老年ACS患者冠状动脉C型病变相关的危险因素依次为高血压病(OR=4.324)、高脂血症(OR=3.732)、FG(OR=1.827)、UA(OR=1.006)、Lpα(OR=1.003),均P<0.05。结论 维吾尔族老年ACS患者冠脉病变特点与汉族老年ACS患者相比,存在民族差异。维吾尔族老年ACS患者冠状动脉C型病变发生率较高,冠状动脉病变程度较汉族老年ACS患者严重。高血压病、高脂血症、FG、UA和Lpα是维吾尔族老年ACS患者冠脉C型病变的危险因素。
Abstract:
AIM To investigate the characteristics of coronary artery lesion, clinical feature in elderly patients with acute coronary syndromes (ACS) of Uygur and Han nationality, and risk factors of Uygur elderly patients with coronary artery C type lesions. METHODS Retrospective analysis of 330 hospitalized patients with a diagnosis of ACS combined with coronary angiography ages≥65 years old; Uygur and Han patients basic data, Lipoprotein a (Lpa), Serum uric acid (UA), Cystatin C (CysC), Retinol binding protein 4 (RBP4), Fibrinogen (FG) and other biochemical indicators. According to the results of coronary angiography coronary artery lesions characterized by coronary artery superiority classification, pathological vascular count, vascular lesions, vascular disease classification, and Gensini points. The subjects were divided into Uygur elderly ACS group (154 cases) and Han elderly ACS group (176 cases). According to the results of coronary angiography in elderly patients with ACS were divided into Uygur elderly patients with ACS type C coronary disease group (99 cases) and Uygur elderly patients with ACS non type C lesion group (55 cases), analyze the risk factors of Uygur with coronary artery C type lesion. RESULTS The coronary artery C type lesion and Gensini score in the Uygur group were significantly higher than that in the Han nationality group (P<0.05). The risk factors of coronary artery C type lesions in Uygur elderly patients with ACS were Hypertension (OR=4.324), Hyperlipidemia (OR=3.732), Fibrinogen (OR=1.827), Uric acid (OR=1.006), Lipoprotein a (OR=1.003), P<0.05. CONCLUSION There were national differences in risk factors among Uygur and Han elderly patients with ACS. The incidence rate of C type lesions in Uygur elderly acute coronary syndrome patients is higher and the degree of coronary lesions were more serious than that of the older Han patients. Hypertension, Hyperlipidemia, Fibrinogen, Lipoprotein a and Uric acid are risk factors for the coronary artery C type lesion in Uygur elderly patients with ACS.

参考文献/References

[1]裘毅钢,李田昌,陈 宇,等.高龄冠心病患者经桡动脉途径介入治疗临床特点分析[J].中国循证心血管医学杂志,2013,5(3):252-254.

[2]He J,Gu DF,Wu XG,et al.Major causes of death among men and women in China[J].N Engl J Med,2005,353(11):1124-1134.

[3]Thygesen K,Alpert JS,Jaffe AS,et al.Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction.Third universal definition of myocardial infarction[J].Circulation,2012,126(16):2020-2035.

[4]Lisiak M,Uchmanowicz I,Wontor R.Frailty and quality of life in elderly patients with acute coronary syndrome[J].Clin Interv Aging,2016,11:553-562.

[5]Han TW,Zhou SS,Li JT,et al.Homocysteine is associated with the progression of non-culprit coronary lesions in elderly acute coronary syndrome patients after percutaneous coronary intervention[J].J Geriatr Cardiol,2016,13(4):299-305.

[6]罗 仁,茶春喜,梁金排.不同年龄组维吾尔族与汉族冠心病患者的危险因素与冠状动脉病变特征分析[J].重庆医学,2014,(4):445-447.

[7]姚 娟,李国庆,雷建新,等.维吾尔族和汉族冠心病危险因素与冠状动脉病变对照分析[J].心血管康复医学杂志,2008,17(1):24-27.

[8]杜晓强,罗 仁,荼春喜,等.维吾尔族与汉族老年冠心病患者冠状动脉病变的临床研究[J].中华老年心脑血管病杂志,2009,11(7):498-501.

[9]马依彤,刘 宇,汤宝鹏,等.新疆维吾尔族与汉族冠状动脉造影对比分析[J].中国介入心脏病学杂志,2001,9(4):211-212.

[10]张鹏宇,朱 勇,王晓华.老年冠心病合并2型糖尿病患者空腹血糖水平与心绞痛及冠脉病变的相关性[J].中国实验诊断学,2013,17(5):933-934.

[11]Yan RT,Yan AT,Tan M,et al.Age-relate differences in the management and outcome of patients with acute coronary syndromes[J].Am Heart J,2006,151(2):352-359.

[12]王 芬,陈 风,过 晶.高龄老年冠心病患者心血管病危险因素分析与干预状况[J].医药前沿,2015,5(33):91-92.

[13]刘春霄,李令娟,许 慧.老年冠心病患者合并危险因素及冠状动脉病变特点[J].中国循证心血管医学杂志,2016,8(3):323-325.

[14]Runetti ND,Cuculo A,Ruggiero A,et al.Coronary atherosclerosis and rare combinination of congenital coronary anomalies in ST-elevation acute myocardial infarction[J].J Cardiowasc Med,2012,14(4):269-270.

[15]De Luca G,Verdoia M,Cassetti E,et al.High fibrinogen level is art independent predictor of presence and extent of coronary artery disease among Italian population[J].J Thromb Thrombolysis,2011,31(4):458-463.

[16]Nursalim A,Suryaatmadja M,Panggabean M.Potential clinical application of novel cardiac biomarkers for acute myocardial infarction[J].Acta Med Indones,2013,45(3):240-250.

[17]Kleczynski P,Legutko J,Rakowski T,et al.Predictive utility of NT pro BNP for infarct size and left ventricle function after acute myocardial infarction in longterm follow-up[J].Dis Markers,2013,34(3):199-204.

[18]Kivity S,Kopel E,Maor E,et al.Association of serum uricacid and cardiovascular disease in healthy adults[J].Am J Cardiol,2013,111(8):1146-1151.

[19]何文彬,秦 勤.急性冠脉综合征患者血清载脂蛋白、脂蛋白a及血浆纤维蛋白原水平的变化及意义[J].山东医药,2013,53(13):57-59.

[20]吴志勤,陈庆伟,吴 庆,等.血清脂蛋白a与冠心病的研究[J].重庆医科大学学报,2011,36(11):1356-1360.

备注/Memo

备注/Memo:
收稿日期:2017-10-31.基金项目:国家自然科学基金项目资助(81160029),新疆维吾尔自治区自然科学基金项目资助(2015211C194) 通讯作者:穆叶赛·尼加提,教授,主要从事急性冠脉综合征研究 Email:muyassar11@aliyun.com 作者简介:依力哈木·阿不力提甫,硕士生 Email:421009928@qq.com
更新日期/Last Update: 1900-01-01