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|本期目录/Table of Contents|

PI3K/Akt信号通路调节心脏功能的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第3期
页码:
344-347
栏目:
综述
出版日期:
2018-03-25

文章信息/Info

Title:
Research progress of PI3K/Akt signaling pathway in regulating cardiac functions
作者:
杨立霞1; 王 楠2; 刘 洋1
（1.甘肃中医药大学临床医学院心血管内科，甘肃 兰州 730000；2.甘肃省人民医院干三心内科,甘肃 兰州 730000）
Author(s):
YANG li-xia1;  WANG Nan2;  LIU Yang1
(1.Department of Cardiology, Clinical College, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, China; 2.Department of Cardiology, Cadre Ward, Gansu Provincial People’s Hospital, Lanzhou 730000, Gansu, China)
关键词:
磷脂酰肌醇-3激酶; 丝（苏）氨酸激酶; 心脏功能; 凋亡
Keywords:
Phosphatidylinositol-3 kinase;  Serine (threonine) kinase;  Cardiac function;  apoptosis
分类号:
R541
DOI:
-
文献标识码:
A
摘要:
PI3K/Akt是调节心脏功能的一条重要的信号转导通路，主要通过血管内皮生长因子介导血管生成、抑制心肌细胞凋亡、重构心室、促进细胞能量代谢等方面调节心脏功能。研究发现PI3K/Akt信号通路在内分泌疾病、肾病、肝纤维化、肿瘤及心血管疾病的发生、发展中起着重要作用。本文就PI3K/Akt信号通路调节心脏功能的分子机制作一阐述。
Abstract:
PI3K/Akt signaling pathway is an important signal pathway in regulating cardiac functions. PI3K/Akt signaling pathway is involved in regulation of cardiac functions through vascular endothelial growth factor (VEGF)-mediated angiogenesis, inhibition of myocardial apoptosis, ventricular remodeling and promoting energy metabolism. This review briefly summarizes PI3K/Akt signaling pathway mediated molecular mechanisms of regulating cardiac functions.

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备注/Memo

备注/Memo:
收稿日期: 2017-03-08.通讯作者：王楠，教授，主要从事心功能不全研究 Email:wangnan2015@163.com 作者简介：杨立霞，硕士生 Email:lixiayang2017@163.com
更新日期/Last Update: 1900-01-01