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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

1994年第2期

页码:

69-71

栏目:

论著

出版日期:

1994-03-01

文章信息/Info

Title:

Effects of para-fural nifidipine on action potential of isolated papillary muscles in guinea pigs

作者:

高 文¹ 贾国良¹ 赵德化²

第四军医大学 1西京医院心脏内科 2药理学教研室 西安 710032

Author(s):

Gao Wen1; Jia Guoliang1; Zhao Dehua2

1Department of Cardiology，Xijing Hospital，2Department of Pharmaco1ogy，Fourth Military Medical University。Xi’an 710032

关键词:

对-呋喃硝苯啶; 动作电位; 乳头肌; 豚鼠

Keywords:

para-fural nifidipine; action potential; papillary muscle; guinea pigs

分类号:

-

DOI:

-

文献标识码:

-

摘要:

对-呋喃硝苯啶(P-Nif)是新近合成的一种药物，为钙拮抗剂硝苯啶的呋喃衍生物。本文采用微电极技术，在离体豚鼠乳头肌上，就P-Nif对乳头肌细胞跨膜动作电位离子流的影响进行了观察。发现30 umol／L的P-Nif可缩短快反应细胞的APD5O、APD90及APD，缩短ERP,同时明显降低慢反应动作电位的幅度和APD50、APD90及V max，提示P-Nif的作用和Nif相似,主要是阻断钙通道。

Abstract:

The recently synthesized para fural nifidipine(P-Nif)is afural derivant of nifidipine.In this experiment we observed the effects of P-Nif on action potential of isolated papillary muscles in guinea pigs by microelectrode technique．It was shown that．P-Nif 30 umol／L reduced action potential duration at 50％，90％ and 100％ repolarization，(APD50,APD90，APD)and prolonged the effective refractory period(ERP).In slown response action potentials P-Nif(30 umol／L)a1so reduced APD50．APD90，APD，and，in the meantime，decreased APA and Vmax These findings suggest that P-Nif exerts effects analogous to Nif by blocking the caIcium channels．

参考文献/References

［1］高 文，赵德化．对-呋喃硝苯啶对离体兔心缺血灌注损伤的保护作用.第四军医大学学报 1992；13(5)：345 .

［2］Pappano AJ．Calcium-dependent action potentials produced by catechelamines in guinea pig atrial muscle fibers depolarized by potassium.Circ Res 1970;27:379.

［3］ Tritthart HA,Volkman R,Weiss R,et al．Calcium mediated action potentials in mammalian myocardium．Naunyn Schmiedebergs Arch Pharmacol 1983；280：239.

［4］Windish H，Tritthart HA．Calcium ion effects on the rising phases of action potentials obtained from guinea Pig papiliary muscles at different potassium concentrations．J Mol Cell Cardlol 1981：13：457.

备注/Memo

备注/Memo:

Received 1992-06-08

常用功能

更新日期/Last Update: 1994-03-01