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小剂量吸入NO降低自主呼吸犬缺氧性肺动脉高压X(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1996年第2期
页码:
77-80
栏目:
论著
出版日期:
1996-03-01

文章信息/Info

Title:
Inhalation of nitric oxide in low dose reduces canine hypoxic pulmonary hypertension at spontaneous breathing
作者:
熊利泽1　曾祥龙1　刘建平2　邓芳霞1　胡　胜1　胡文能1　刁兴文1　廖建军3
第四军医大学西京医院　1麻醉科　2心脏外科　3呼吸内科　西安　710033
Author(s):
Xiong Lize1;  Zeng Xianglong1;  Liu Jianping2;  Deng Fangxia1;  Hu sheng1;  Hu Wenneng 1; Diao Xingwen1; Liao Jianjun3
1Department of Anesthesiology , 2epartment of Cardiovascular Surgery, 3Department of Respiration Medicine, Xijing Hosp ital, Fourth Military Medical University,Xi′an 710032
关键词:
一氧化氮;  缺氧症;  高血压;  肺性;  狗
Keywords:
nitric oxide;  hypoxia;  pulmonary hypertension;  dogs
分类号:
-
DOI:
-
文献标识码:
-
摘要:
本文观察国内配制一氧化氮(NO) 气体对缺氧性肺动脉高压的作用。使9条麻醉犬吸入氧浓度从0.36±0.09 降至0.08±0.02, 然后吸入90±8 ppm NO , 结果发现缺氧后, 平均肺动脉压、肺循环阻力、平均股动脉压和心输出量显著增加, 呼吸及心率增快, 血气分析示过度通气; 吸入NO 后, 增高的平均肺动脉压和肺循环阻力显著下降(P<0.05) , 而平均股动脉压、心输出量、体循环阻力、心率无明显变化; NO 吸入10 min 时血中高铁血红蛋白浓度从0.3±0.1% 升至0.7±0.5%。说明如控制吸入NO 剂量及严密监测, 可将该气体试用于临床, 从而选择性降低肺动脉高压。
Abstract:
The effect of nitric oxide produced by Beijing Beifen Scienti ic Gas Co.on anoxic pulmonary hypertension was ob served in nine anesthetized dogs at spontaneous breathing in this study.When FiO2 was decreased from 36±9% to 8±2% and 90±8 ppm NO was given. The results showed that after hypoia, the mean pulmonary arterial p ressure(MPAP), the pulmonary vascular resistance (PVR ) , the mean blood pressure (MBP) , the cardiac output(CO),the respiratory rate and the heart rate increased significantly; blood gas analysis showed hyperventilation.When NO was inhaled, increased MPAP and PVR were decreased (P< 0.05),but MBP、CO、the heart rate and the systemic vascular resistance had no obvious changes (P> 0.05).Methaemoglobin increased from 0.3±0.1% to 0.7±0.5%(P<0.05) 10 min after inhalation of NO. It is proved that the gas could be used for pat ients with pulmonary hypertension to selectively dilate pulmonary vasculature at low dose inhalation of NO and under close monitoring.

参考文献/References

［1］熊利泽, Young JD, 曾祥龙. 一氧化氮—— 一种特异性肺血管舒张剂: 研究进展及展望( 综述).国外医学麻醉与复苏分册1993; 14: 129.

［2］Snow DJ , Gray SJ , Ghosh S, et al.Inhaled nitric oxide in patients with normal and increased pulmonary vascular resistance after cardiac surgery. Br J Anaesth 1994; 72: 185.

［3］igatello LM , Hurford WE, Kacmarek RM , et al. Prolonged inhalation of low concentrations of nitric oxide in patients with severe adult respiratory distress syndrome. Anesthesiology 1994; 80: 761.

［4］李影林, 主编.临床医学检验手册.长春: 吉林科学技术出版社, 1987: 85.

［5］Aitkenhead AR, Smith G, eds.Textbook of anaesthesia1 2nd ed. Edinburgh: Churchill Livingstone,1990: 728.

［6］Young JD, Dyar OJ , Xiong LZ, et al.Methaemoglobin production in normal adults inhaling low concentrations of nitric oxide. Intensive Care Med 1994; 20: 581.

［7］Young JD, Dyar OJ , Xiong LZ, et al.Effect of methylene blue on the vasodilator action of inhaled nitric oxide in hypoxic sheep.Br J Anaesth 1994; 73: 511.

［8］Etches PC, Finer NN , Barrington KJ , et al.Nitric oxide reverses acute hypoxic pulmonary hypertension in the newborn piglet.Pediatr Res 1994; 35: 15.

［9］Yamaguchi T , O ′Brien RF, Hanson WL , et al.Prostacyclin contributes to inhibition of hypoxic pulmonary vasoconstrict ion by alkalosis.Prostaglandins 1989 ; 38: 53.

备注/Memo

备注/Memo:
Received 1995-08-17 X总后医药卫生回国人员科研活动基金资助
更新日期/Last Update: 1996-03-01