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一氧化氮受抑制后冠脉血小板功能的变化(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1997年第1期
页码:
8-10
栏目:
论著
出版日期:
1997-01-01

文章信息/Info

Title:
Change of platelet aggregation rate and 6-keto-PGF1a levels in coronary circulation after inhibition of nitric oxide in anesthetized dogs
作者:
刘庆军1　吴明媚2　王跃民3　臧益民3
1 解放军第91 医院心内科 兖州 272000 第四军医大学　2 唐都医院心内科　3生理学教研室
Author(s):
Liu Qingjun1;  Wu Mingmei2;  Wang Yaomin3and Zang Yimin3
1Department of Cardiology, 91th Hospital of PLA , Yanzhou 272000 2Department of Cardiac Internal Medicine, Tangdu Hospital , Xi′an 3Department of Physiology, Fourth Military Medical University,Xi′an
关键词:
冠状动脉循环　一氧化氮　血小板凝集　狗
Keywords:
coronary circulation　　nitric oxide　　platelet aggregation　　dogs
分类号:
-
DOI:
-
文献标识码:
-
摘要:
分别用放射免疫法(RIA)和二磷酸腺苷诱导法, 测定了犬冠脉内灌注N-单甲基左旋精氨酸(L-NMMA)5mg/kg 前后, 前降支(LAD) 伴行静脉血中6-酮-前列腺素F1a(6-酮-PGF1a) 的含量和血小板聚集率(PAgR)。结果表明,L 2-NMMA 灌注后血小板聚集率由31.3%±6.6%升至43.3%±6.2% (P< 0.01),但6-酮-PGF1a没有明显变化。以上结果提示内源性一氧化氮合成受抑制时, 冠脉循环中PAgR增加, 而前列腺素无变化。
Abstract:
Platelet aggregation rate and 6-keto-PGF1a levels of left in terventricular venous blood were determined by ADP technique and radioimmunoassay both before and after a 5 mg/kg intracoronary infusion of N-monomethyl-L-2arginine (L-NMMA)in open-chest anesthetized dog. L-NMMA induced an increased platelet aggregation rate (x±s, from 31.3±6.6% to 43.3±6.2% ,P <0.01) ,6-keto-PGF1a levels, however, remained unchanged. The above results suggested that inhibition of intrinsic nitric oxide synthesis enhances platelet aggregation, but with no effect on PGI2

参考文献/References

［1］刘庆军, 吴明媚, 臧益民. 犬冠脉动脉灌注N-单甲基左旋精氨酸对冠状循环中内皮素-1含量的影响. 中国循环杂志, 1995; 61: 191.

［2］李振甲, 主编. 实用放射免疫学. 北京: 科学技术出版社, 1989: 198～ 211.

［3］赵志青,朱妙章,臧益民, 等.心肌缺血区血液和体静脉血液血小板功能变化. 中国循环杂志,1989; 4: 270.

［4］Willerson JT , Golino P, Eidt J , et al. Specific platelet mediators and unstable coronary artery lesions: Experimental evidence and potential clinical implication. Circulation,1989; 80: 198.

［5］Mark WI, James H, John C, et al. Circulating endothelin during acetycholine-induced coronary vasoconstriction in hypercholesterolemic pig.JACC, 1993; 21 (2) : 125A.

备注/Memo

备注/Memo:
Received 1996-03-03；revised 1996-12-06
更新日期/Last Update: 1997-01-01