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肾性高血压左室肥厚及药物逆转时心肌的力学变化(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1998年第4期
页码:
221-224
栏目:
论著
出版日期:
1998-07-01

文章信息/Info

Title:
Renal hypertensive LV hypertrophy and mechanical changes in myocardium affter the reverse with drugs
作者:
陈亦刚
湖北中医学院生理学教研室　武汉 430061
Author(s):
Chen Yigang
Teaching and Research Section of Physiology, Hubei College of Traditional Chinese Medicine,Wuhan, 430061
关键词:
高血压;  肾性　心肌肥厚　甲基多巴　米诺地尔　大鼠
Keywords:
hypertension;  renal　myocardial hypertrophy　methyldopa　minoxidil　rats
分类号:
-
DOI:
-
文献标识码:
-
摘要:
建立大鼠肾血管性高血压心肌肥厚模型, 高血压持续6周和11周后均产生左心室肥厚。给高血压持续6周大鼠分别饲以α-甲基多巴(a-MD) 和长压定(米诺地尔,Mino) , 4周后α-MD 组肥大心肌部分逆转,α-MD降压作用低于Mino;Mino降压作用显著, 但Mino 组肥大心肌却未见明显好转。对各组大鼠用左室导管法测定大鼠在体心肌力学性能, 高血压持续6周及11周时大鼠肥厚心室之性能均已受损, 以11周时更甚; 饲药后α-MD组心肌力学性能明显好转,Mino组亦有所改善。揭示: 高血压肥厚心肌的功能通常要降低, 无论是血压还是心肌质量的逆转均有利于心肌功能的恢复。
Abstract:
Models of renovascular hypertensive rats (RHR) were made. There was a significant left ventricular hypertrophy (LVH) in the rats 6 w and 11 w after the 2K1C operation. Rats made hypertensive for 6 w were treated with a-methyldopa (α-MD) or minoxidil (Mino) for 4 w so as to reverse cardiac hypertrophy and hypertension. α-MD reversed LVH and renal hypertension which decline to a certain degree; Mino reversed renal hypertension nearly to the normal level,but exerted no obvious effect on cardiac hypertrophy. The cardiac function of conscious rats in each group was measured by a retained duct in the left ventricle (LV). The results suggest that the mechanical property of hypertrophic myocardium from hypertension was spoilt, and the diastolic function and cardiac reserve declined more obviously; The above damages of reversed myocardium and hypertrophied myocardium after the relief of hypertension were partially repaired(P<0.05) ; The β-receptor responsiveness of reversed myocardium had recovered but the cardiac relaxant reserve was still poor. In short, either reversing myocardiac hypertrophy or declining hypertension was beneficial to the recovery of cardiac function and cardiac reserve of RHR.

参考文献/References

［1］Fernandez PG, Snedden W , Idikio H, et al. The reversal of left ventricular hypertrophy with control of blood pressure in experimental hypertension. Scand J Lab Invest, 1984; 44: 711.

［2］张晓霞. 高血压性心肌肥厚与左室功能状态. 国外医学(生理、病理科学与临床分册) , 1987; 7 (4) : 210.

［3］Tarazi RC, Frohlich ED. Is reversal of cardiac hypertrophy a desirable goal of nti-hypertensive therapy? Circulation, 1987; 75(suppl Ⅰ) :Ⅰ-13.

［4］曲毓敏. 高血压左心室重构及对心脏功能的影响. 中国心血管杂志, 1997; 2 (3) : 175.

［5］丁小凌, 李云霞. 大鼠肾血管性高血压心肌肥厚的产生和逆转.湖南医科大学学报, 1989; 14 (3) : 209.

［6］刘正清, 陈亦刚, 李云霞, 等. 高血压左室肥厚及药物逆转时心肌形态和酶组化的变化. 湖南医科大学学报, 1992; 17 (2) : 117.

[7]Vogt M , Strauer BE. Response of hypertensive left ventricular hypertrophy and coronary microvascular disease to calcium antagonists. Am J Cardiol, 1995; 76: 24D.

[8]Oren S, Grossman E, Frohlich ED. Reduction in left ventricular mass in patients with systemic hypertension treated with enalapril, lisinoril, or fosenopril. Am J Cardiol, 1996; 77: 93.

[9]Capasso JM , Strobeck JE,Malhotra A , et al. Contractile behaviorof rat myocardium after reversal of hypertensive hypertrophy.Am J Physiol, 1982; 242: H882.

[10] Pegram BL , Frohlich ED. Cardiovascular adjustment of antiadrenergic agents. Am J Med , 1983; 75 (3A ) : 94.

[11]Drayer JI, Gardin JM ,Weber MA , et al. Cardiac muscle mass during vasodilation therapy in hypertension. Clin Pharmacol Ther, 1983; 33: 727.

[12]Pauletto P,Vescovo G, Scannapieco G, et al. Change in rat ventricular isomyosins with regression of caridiac hypertrophy. Hypertension, 1986; 8 (12) : 1143.

[13]Wicker P, Tarazi RC, Kobayashi K. Coronary blood flow during the development and regression of left ventricular hypertrophy in renovascular hypertensive rats. Am J Cardiol, 1983; 51 ( 10) :1744.

备注/Memo

备注/Memo:
(收稿1998-04-06　修回1998-08-10)
更新日期/Last Update: 1998-07-01