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Title:: Effects of xuefuzhuyutang on cardiac haemodynamics in coronary artery critical stenosis in dogs

作者:: 李树壮¹; 姜艳华¹; 林英²; 丁鸿雁¹; 朱波¹; 曲秋连¹; 马丽旭¹; 王允杰¹; 1 解放军大连医学高等专科学校生理学教研室, 辽宁大连116017; 2 沈阳军区联勤部大连第二干休所

Author(s):: LI Shu-zhuang¹; JIANG Yan-hua¹; LIN Ying²; DING Hong-yan¹; ZHU Bo¹; QU Qiou-lian¹; MA Li-xu¹; WANG Yun-jie¹; 1PLA Dalian Junior College of Medicine, Dalian 116017, Liaoning, China; 2Shenyang Army District Logistics Ministry the Second Cardre Sanatorium in Dalian

关键词:: 血府逐瘀汤; 冠状动脉; 临界狭窄; 血流动力学; 狗

Keywords:: xuefuzhuyutang; coronary artery; critical stenosis; cardiac haemodynamics; dog

分类号:: R286;R331.3

DOI:: -

文献标识码:: A

摘要:: 在12条麻醉开胸犬上,用微米狭窄器造成冠状动脉前降支临界狭窄。测定平均动脉压(MAP)、左心室收缩压(LVSP)、左心室舒张压(LVDP)、室内压最大上升速率(+dp/dtmax)、室内压最大下降速率(-dp/dtmax)及心排出量(CO)等血流动力学指标,在冠脉临界狭窄基础上,观察用血府逐瘀汤前后心功能的改变。结果表明冠脉临界狭窄时,LVDP明显升高(P＜0.05),LVSP,+dp/dtmax、-dp/dtmax及CO明显降低(P＜0.05),给血府逐瘀汤后,上述指标明显好转，表明心肌缺血造成的心脏功能损害减轻。

Abstract:: In 12 open chest mongrel dogs coronary artery critical stenosis were produced by a micrometer constrictor on anterior descending coronary artery. The effects of xuefuzhuyutang on the myocardial ischemia model was observed by measuring the mean artery pressure (MAP), the left ventricular diastolic pressure (LVDP), maximal rise in left ventricular pressure (dp/dtmax),maximal fall in left ventricular pressure (-dp/dtmax) and the cardiac output (CO)etc. The results showed that the LVDP was significantly increased and the MAP,CO,dp/dtmax and -dp/dtmax were lowered during the period of coronary artery critical stenosis. By taking xuefuzhnyutang in the mediacted group,cardiac function was significantly improved.

参考文献/References

［1］胡克武. 血府逐瘀汤治疗冠心病心绞痛临床观察［J］. 湖北中医杂志,1997，19(4):14.

［2］陈士良,臧益民,潘　真，等. 冠脉狭窄对心脏功能的影响［J］. 中国病理生理杂志,1988，4(5):276.

［3］李树壮,臧益民,杨继庆,等. 潘生丁对不同程度缺血心脏的作用［J］. 第四军医大学学报,1990，11(3):215.

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血府逐瘀汤对犬冠状动脉临界狭窄血流动力学的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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