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冠状动脉内支架安置术后纤溶及前列腺素水平的变化及其临床意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第4期
页码:
263-265
栏目:
论著
出版日期:
2000-08-01

文章信息/Info

Title:
The clinical significance of the change in fibrinolytic activity and prostaglandin level with introcoronary stent
作者:
李志立1;  李妍2;  贾国良2;  徐海峰3;  周润锁3
第四军医大学: : 11 唐都医院心内科, 陕西西安710038; 21 西京医院心内科; 31 唐都医院核医学科
Author(s):
LI Zhi-li; 　LI Yan; 　JIA Guo-liang; 　XU Hai-feng; 　ZHOU Run-suo
Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi'an Shaanxi, 710038, China
关键词:
冠状动脉疾病; 支架; 组织型纤溶酶原激活剂; 前列腺素
Keywords:
coronary disease; stent;  tissue type plasminogen activator;  prostaglandin
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 观察冠心病患者冠状动脉内支架(ICS)安置术后外周血中纤溶和前列腺素水平的变化及其临床意义。方法 将24例患者分为肝素涂层支架组（n＝9）和普通支架组(n=15), 测定ICS术前、术后2,24 h,7 d血浆血栓素B2(TXB2)、6-酮－前列腺素F1α (PGF1α)、组织型纤溶酶原激活物(t-PA)及其抑制物 (PAI-1)的变化。结果 肝素支架组与普通支架组术后T X B2,PGF1α 明显升高，术后24 h达高峰；t-PA与PAI-1术后无明显变化。结论 ICS术后确有血小板活化，纤溶活性变化不大。肝素支架组与普通支架组并无显著差别。
Abstract:
AIM To study the active changes of the fibrinolysis and the prostaglandin undergoing introcoronary stent (ICS)in the patients with coronary heart disease in order to guide the clinical drug usage. METHODS The patients were divided into heparin-coated stent (n=9)and non-coated stent (n=15) groups and we determined the concentrations of thromboxane B2(TXB2), 6-Keto-prostaglandin F1α(6-Keto-PGF1α ), tissue type plasminogen activator (tPA)and plasminogen activator inhibitor-1(PAI-1)in 2,24 hours and 7 days after ICS. RESULTS Both of the TXB2 and 6-Keto-PGF1α were higher after ICS than before, rising to the peak at 24, but tPA and PAI-1 had no significant changes. CONCLUSION Platelet may be activated after ICS and the fibrinolysis were the same as before. There are no significant differences between the heparin-coated stent and non-coated stent groups.

参考文献/References

[1] 黄震华，徐培民. 安放冠脉内支架后血栓形成：决定因素和预防措施［J］.心血管病学进展,1997，18(4):196.

［2］ 李振甲. 实用放射免疫学［M］. 北京:北京科学技术文献出版社,1989. 198～221.

［3］ Langford EJ, Brown AS,Wainurig RJ,et al. Inhibition of platelet activity by S-nitrosoglutathione during coronary angioplasty［J］. Lancet, 1994, 344(8935):1458.

［4］ 蒲晓群, 张之炯, 郑艳珍, 等. 冠心病的抗凝血酶III与纤溶改变及其临床意义［J］. 临床心血管病杂志,1998,14(6)：332.

［5］ Hsu LC. Principales of heparin-coating techniques［J］. Perfusion, 1991,6(2):209.

［6］Serruys PW, Emanuelsson H, Van der Giessen W, et al. Heparin-coated Palmaz-schatz in human coronary arteries. Early outcome of the Benestent-II pilot study［J］. Circualtion,1996, 93(3): 412.

备注/Memo

备注/Memo:
收稿日期：1999-10-15.
更新日期/Last Update: 2000-08-01