CIC-1氯离子通道的非均衡性门控及其对细胞外氯离子浓度的依赖性(PDF)
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2001年第2期
- 页码:
- 87-89
- 栏目:
- 论著
- 出版日期:
- 2001-03-01
文章信息/Info
- Title:
- Nonequilibrium gating of CIC-1 chloride channel and its dependence on extracellular chloride concentration
- Author(s):
- ZHANG Xiao-dong; ZANG Yi-min; ZHOU Shi-sheng
- Department of Physiology，Fourth Military Medical University，Xi'an Shaanxi 710032，China
- Keywords:
- CIC-1; ion channels; gating; Xenopus oocytes
- 分类号:
- R337.5
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- CIC-1是一种具有电压依赖门控特性的氯离子通道。但这种通道的门控机制与其他电压门控的阳离子通道有很大的差别。为探讨CIC-1离子通道的门控机制，本文应用爪蟾卵母细胞异源性表达野生型CIC-1氯离子通道，并通过改变细胞外氯离子浓度，对其门控机制进行了研究。结果表明，CIC-1氯离子通道的门控具有对电压和氯离子浓度的双重依赖性．这提示一种非均衡性的门控机制。
- Abstract:
- CIC-1 is a voltage-dependent chloride channe1．But its gating mechanism is different from the voltage-dependent cation channels．CIC-1 gating mechanism is discussed in this paper by heteroexpression of this channel in Xenopus oocytes and by changing extracellular chloride concentration．It is concluded that CIC-1 gating is both voltage and chloride concentration dependent which suggests a nonequilibrium gating mechanism.
参考文献/References
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[4]张晓东，臧益民,谢安．用于离子通道基因表达的爪蟾卵母细胞的分离和培养[J]．心脏杂志，2OO1；13(2)：120．
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备注/Memo
- 备注/Memo:
- 收稿日期：2000-l1-O1.
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更新日期/Last Update: 2001-03-01