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肾上腺素受体在心肌细胞肥大中的作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第5期
页码:
340-342
栏目:
论著
出版日期:
2001-09-01

文章信息/Info

Title:
Role of adrenergic receptor in hypertrophy of cardiac myocyte
作者:
谢协驹;  符史干;  吉丽敏
海南医学院病理生理学教研室, 海南海口571101
Author(s):
XIE Xie-ju;  FU Shi-gan;  JI Li-min
Department of Pathophysiology, Hainan Medical College, Haikou Hainan 571101, China
关键词:
受体;  肾上腺素能;  肾上腺素能受体阻滞剂;  心肌细胞肥大;  细胞培养
Keywords:
receptors;  adrenergic;  adrenergic recepter blockaders;  hypertrophy of cardiacm yocyte; cell culture
分类号:
R363
DOI:
-
文献标识码:
A
摘要:
目的 观察A受体阻滞剂酚妥拉明和B受体阻滞剂心得安对肾上腺素诱导的心肌细胞肥大的作用。方法 用培养的新生大鼠心肌细胞, 测量其表面积和[3H]-亮氨酸([3H]-Leu) 的掺入量来判断心肌细胞肥大。结果 肾上腺素可明显增加心肌细胞表面积和[3H]-Leu 的掺入量, A, B受体阻滞剂能阻断肾上腺素增加心肌细胞表面积和[3H]-Leu 掺入量。结论 A, B受体阻滞剂有减轻肾上腺素诱导心肌细胞肥大的作用。
Abstract:
AIM To investigate the relation of alpha-adrenergic receptor blocking agents (phento lamine) and beta-adrenergic receptor blocking agents (propranolol) in adrenaline-induced the hypertrophy of cardiomyocyte. METHODS The measurement of cell surface area and [3H]-Leucine incorporation judged the hypertrophy of cardiom yocyte in cultured neonatal rat myocardal cells. RESULTS Adrenaline could significantly increase cell surface area and promote [3H]-Leucine incorporation, alpha-and beta-adrenergic blocking agents could markedly block effects of adrenaline increasing cell surface area and promoting [3H]-Leucine incorporation.CONCLUSION Alpha-and beta-adrenergic blocking agents can prevent the hypertrophy of cardiomyocytes induced by adrenaline in cultured neonatal rat myocardal cells.

参考文献/References

[1] Simpson PC, Kariya K, Karns LR, et al. Adrenergic hormones and control of cardiac myocyte growth [J]. Mol Cell Biochem ,1991, 104 (1- 2) : 35- 43.

[2] Lahteenmaki TA , Sievi E,Vapaatalo H. Antihypertensive drugs reduce noradrenaline-induced hypertrophy of cultured myocardial cells [J]. J Pharm Pharmacol, 1996, 48 (3) : 323-326.

[3] Bogoyevitch MA , Andersson MB, Gillespie Brown J , et al.Adrenergic receptor stimulation of themitogen-activated protein kinase cascade and cardiac hypertrophy [J]. Biochem J , 1996,314 (Pt1) : 115- 121.

[4] 陈国伟, 伍贵富. 心力衰竭[A]. 杨惠玲, 潘景轩, 吴伟康, 等. 高级病理生理学[M]. 北京: 科学出版社, 1998. 244.

备注/Memo

备注/Memo:
收稿日期：2000-11-13.
更新日期/Last Update: 2001-09-01