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冠心病患者血浆降钙素基因相关肽和内皮素-1水平的临床研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第4期
页码:
314-315
栏目:
临床研究
出版日期:
2002-07-01

文章信息/Info

Title:
Relationship between plasma CGRP and ET-1levels in patients with coronary heart disease
作者:
宋哲峰;  王祝新;  张文礼;  苏晓飞;  施洪超;  黄 芸
南京雨花医院,江苏南京210012
Author(s):
SONG Zhe-feng ; WANG Zhu-xin;  ZHANG Wen-li;  SU Xiao-fei;  SHI Hong-chao;  HUANG Yun
Yuhua Hospital,Nanjing,Jiangsu 210012,China
关键词:
心肌梗死; 急性; 心绞痛; 降钙素基因相关肽; 内皮缩血管肽类
Keywords:
myocardidl infarction;  acute;  angina pectoris;  calcitonin gene-related peptide; endothelins
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 观察冠心病患者血浆降钙素基因相关肽(CGRP)和内皮素-1(ET-1)在发病时和治疗后含量的变化。方法 以放射免疫法测定12例急性心肌梗死(AI)、33例心绞痛(AP)患者发病第1天和治疗后第7天的CGRP及ET-1含量,并与20例正常人对照。结果 AMI组和AP组第1天CGRP较对照组增高(P<0.05),两组的ET-1明显增高,有非常显著差异(P<0.01)。治疗后第7天两组数据与对照组相比无明显差异(P>0.05)。结论 CGRP与ET-1在冠心病发病早期均有不同程度地增高,两者之间显著正相关,并与冠心病的严重程度相关。
Abstract:
AIM To investigate the changes in calcitonin gene-related peptide (CGRP) and endothelin-1(ET-1) in plasma from coronary heart disease patients at the time of onset and after the treatment.METHODS The CGRP and ET-1 contents of 12 acute myocardial infarction (AMI) cases and 33 angina pectoris(AP) cases were meaesured by radioimmunoassay on the first day of onset and the seventh day after the treatment. Meanwhile,the plasma from 20 normal people was used as the control.RESULTS On the first dog,the contents of CGRP from groups of AMI and AP patients were higher than those from the normal control(P<0.05),and the contents of ET-1 from the two groups increased obviously. There was a significant difference between them(P<0.01). After 7 days of treatment,the results between the patients and normal controls showed no significant difference(P>0.05).CONCLUSION Both CGRP and ET-1 increase at the early stage of the disease,and they are positively related with the seriousness of coronary heart disease.

参考文献/References

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[5] 黄振平,鲍正毅,丁世忠,等.冠心病患者血浆降钙素基因相关肽水平的临床观察[J].中国老年学杂志,1998,18(5):278.

[6] 陈 炜,王永志,邢红云,等.冠心病患者血浆血管活性肽的动态变化及意义[J].铁道医学,1999,27(4):235.

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备注/Memo

备注/Memo:
收稿日期：2001-03-16.
更新日期/Last Update: 2002-07-01