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心力衰竭患者血清中TNF-α,IL-1及IL-6的变化及培哚普利对其影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第4期
页码:
318-320, 322
栏目:
临床研究
出版日期:
2002-07-01

文章信息/Info

Title:
TNF-α,IL-1and IL-6in patients with congestive heart failure and their changes after perindopril treatment
作者:
王晓明1; 李 源1; 李慧芳1; 臧益民2; 贾国良3
第四军医大学:1.西京医院老年病科,2.生理学教研室,3.西京医院心脏内科,陕西西安710032
Author(s):
WANG Xiao-ming1; LI Yuan1; LI Hui-fang1; ZANG Yi-min2; JIA Guo-liang3
1.Department of geriatrics, 3.Department of cardiology, Xijing Hospital, 2.Department of physiology. Fourth Military Medical University, Xi' an, Shaanxi 710032, China
关键词:
心力衰竭; 充血性; 培哚普利; 肿瘤坏死因子-α; 白细胞介素-1; 白细胞介素-6
Keywords:
heart failure;  congestive;  perindopril;  tumor necrosis factor-α;  interleukin -1; interleukin-6
分类号:
R541
DOI:
-
文献标识码:
A
摘要:
目的 探讨心力衰竭(CHF)患者血清中TNF-α,IL-1及IL-6的变化及培哚普利对其水平的影响。方法 采用放射免疫方法检测42例服用培哚普利的CHF患者、42例常规治疗CHF患者治疗前后及30例健康人血清中TNF-α,IL-1及IL-6的水平。结果:①84例CHF患者较健康人血清中TNF-α,IL-1及IL-6显著增高(P<0.01),且随着心功能损害程度加重而升高。②培哚普利组与常规治疗组治疗前后血清中TNF-α,IL-1及IL-6水平有显著性差异(P<0.01),且培哚普利组较常规治疗组治疗后血清中TNF-α,IL-1及IL-6降低更为明显。结论 CHF患者TNF-α,IL-1及IL-6水平与心功能状态密切相关。培哚普利比常规治疗具有较明显降低TNF-α,IL-1及IL-6的水平的作用,可减缓心脏损伤的进程,达到保护和改善CHF患者的心功能。
Abstract:
AIM To investigate the effects of perindopril on cardiac function and serum levels of tumor necrosis factor-α(TNF-α) ,interleukin -1(IL-1), and interleukin-6(IL-6) in patients with congestive heart failure (CHF).METHODS The levels of serum TNF-α,IL-1 and IL-6 were determined by radioimmunoassay in 84 CHF cases (42 of whom were treated by perindopril and other 42 were treated by conventional treatment) and 30 health cases as control.RESULTS ①The levels of TNF-α,IL-1 and IL-6 in all the 84 CHF cases were much higher than those of the control cases (P<0.01) and increased significantly in CHF cases with the decreased cardiac function.②The levels of TNF-α,IL-1 and IL-6 decreased 2 weeks after the treatment in both perindopril group and conventional group, but the levels after perindopril treatment trended to decrease more significantly than the after conventional group (P<0.01).CONCLUSION It shows the close relationship between cardiac function status and levels of serum TNF-α,IL-1 and IL-6 in patients with CHF. Perindopril may protect and improve cardiac function by decreasing TNF-α,IL-1 and IL-6 levels in patients with CHF.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2002-02-08.
更新日期/Last Update: 2002-07-01