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|本期目录/Table of Contents|

叶酸对急性心肌梗死患者血清同型半胱氨酸及反应蛋白C的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第1期
页码:
57-59
栏目:
临床研究
出版日期:
2004-01-01

文章信息/Info

Title:
The effects of folic acid on plasma homocysteine and C-response protein of patients with acute myocardial infarction
作者:
党波; 张立博; 陈春波
中原油田总医院心内科,河南 濮阳 457001
Author(s):
DANG Bo;  ZHANG Li-bo; CHEN Chun-bo
Department of Cardiology, Zhong yuan Oil Field General Hospital, Puyang,Henan 457001 China
关键词:
叶酸; 心肌梗塞; 急性; 同型半胱氨酸; C-反应蛋白
Keywords:
folic acid; myocardial acute infarction; homocysteine; C-responds protein
分类号:
R542.22
DOI:
-
文献标识码:
A
摘要:
目的:观察急性心肌梗死(AMI)患者急诊经皮冠脉成形术(PTCA)后口服叶酸对血清中 反应蛋白C(CRP)及同型半胱氨酸(Hcy)浓度的影响,进而为叶酸在 AMI患者中的应用提供依据。方法:选择行急诊 PTCA的 AMI患者共 24例,分为两组,其中一组给予叶酸 5mg,1次/d口服,另外一组不予叶酸口服,其余常规治疗均相同。分别在治疗前及治疗后取血测定血清中叶酸、HcyCRP的浓度并加以比较。结果:治疗后Hcy的浓度在叶酸组(8.3±1.7molL /)及对照组(11.3±7.2mol/L)均有下降,差异均有统计学意义,但是叶酸治疗组的 Hcy浓度下降更多,二者的差异有显著性。治疗后血清中 CRP的浓度在叶酸组(4.7±3.9mg/L )及对照组(3.7±2.0mg/L)均较治疗前下降,差异有统计学意义,但是两组间 CRP下降程度的差异没有统计学意义。结论:及时补充叶酸可以更有效地使 AMI患者血清中 Hcy的浓度下降,但并不能使血清中 CRP的浓度进一步下降。
Abstract:
AIM:To investigate the effects of folic acid on the plasma homocysteine and C-responds protein of patients with acute myocardial infartion(AMI) so as to provide evidence for prompt application of folic acid to AMI patients. METHODS: 24 cases were selected and divided into two groups. All of them underwent percutaneous transluminal coronary angioplasty immediately after diagnosised. Then one group were given folic acid orally(5mg/d) in addition to routine treatment, and the other group were treated with routine treatment only.The blood sample of the two groups were assayed pre- and post-treatment(two weeks later), and the concentrations of folic acid, homocysteine and CRP were measured and compared. RESULTS: The Hcy concentrations of post-treatment were lower than those of pre-treatment in both groups, but the lowering degree in the folic acid group was greater than those of the control group and the difference is significant(P<0.05). Th concentrations of CRP of post-treatment in both groups werel ower than those of pre-treatment and the difference was significance(P<0.05), but the lowering degrees of both groups were not significantly different. CONCLUSION: Taking folic acid in time after AMI could lower the Hcy concentration more efficiently, but couldn't lower the CRP concentration.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2002-9-25
更新日期/Last Update: 2004-01-01