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冠心病患者血浆同型半胱氨酸和高敏C2反应蛋白与冠状动脉病变支数的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第5期
页码:
446-448
栏目:
临床研究
出版日期:
2004-09-01

文章信息/Info

Title:
Relationship of the levels of plasma homocystein and high-sensitivity C-reactive protein with the number of stenosed coronary vessel in CHD patients
作者:
潘　棱;  沈晓丽;  林立芳;  陈诗泉;  吴志勇;  浦晓东;  胡锡衷
福建省心血管病研究所,福建福州350001
Author(s):
PAN Leng ;  SHEN Xiao-li ;  LIN Li-fang ;  CHEN Shi-quan ;  WU Zhi-yong ;  PU Xiao-dong ;  HU Xi-zhong
Fujian Provincial Institute for Cardiovascular , Fujian Provincial Key Laboratory of Cardiovascular Diseases. Fuzhou , Fujian 350001 ,China
关键词:
同型半胱氨酸;  高敏C2反应蛋白;  冠状动脉病变
Keywords:
homocystein ;  high-sensitivity C-reactive protein ;  stenosed coronary vessel
分类号:
R543. 3
DOI:
-
文献标识码:
A
摘要:
目的:探讨冠心病患者血浆同型半胱氨酸(HCY) 和高敏C-反应蛋白(hs-CRP) 与冠状动脉病变支数的关系。方 法:选择在我院住院并进行冠状动脉造影的患者102 例,以冠状动脉造影未发现任何可辨认的斑块或狭窄者列入 对照组(43 例) ,将至少有一支血管狭窄≥50 %者列入冠心病组(59 例) ,并根据冠状动脉病变支数进一步分为单支 病变组(21 例) ,双支病变组(17) 和3 支病变组(21 例) 。冠状动脉造影前取静脉血待测HCY和hs2CRP。HCY检测 采用荧光衍生化后HLPC分离法。hs-CRP 检测以高敏感酶联免疫吸附试验定量检测。结果: 冠心病组的血浆HCY 和hs-CRP 水平显著高于对照组( P < 0. 01) 。除了单支病变组的hs-CRP 与对照组无显著差异外,其余冠状动脉病变 组的血浆HCY和hs-CRP 水平均高于对照组( P < 0. 05) 。血浆HCY与冠状动脉病变支数相关( r = 0. 448 , P < 0. 01) 。hs-CRP 与冠状动脉病变支数相关( r = 0. 350 , P < 0. 01) 。结论: 血浆HCY、hs-CRP 与冠状动脉病变程度呈正相 关。 关键词:
Abstract:
AIM: To investigate the correlation of elevated plasma homocystein (HCY) and concentration of high2sensitivity C-reactive protein (hs-CRP) with the number of stenosed coronary vessel in CHD patients. METHODS : 102 subjects who underwent coronary angiography in our hospital were included in this study. Cases ( n = 59) with ≥50 % stenosis in at least one of the three coronary vessels were angiographically defined as having coronary heart disease (CHD) . While subjects ( n = 43) without stenosis in all the three coronary vessels were considered as controls. CHD cases were divided into single2vessel ( n = 21) , double2vessel ( n = 17) and triple-vessel group ( n = 21) . Plasma HCY and hs-CRP was measured before angiography in all subjects. Plasma HCY levels were measured using high-performance liquid chromatography with fluorescence detection. High-sensitivity ELISA test was used to quatitatively detect plasma hs-CRP. RESULTS : Mean plasma HCY and hs-CRP level was significantly higher in CHD patients than in controls( P < 0. 01) . The number of stenosed coronary vessel was positively related to plasma HCYand hs2CRP level . CONCLUSION: Plasma HCY and hs2CRP level was correlated to extent of coronary artery culprit lesion.

参考文献/References

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[2 ] Magott M. Homocysteine as a nonlipid factor in the pathogenesis of atherosclerosis[J ] . Postepy Hig Med Dosw , 1998 ,52 :259 - 267.

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[7 ] 王兴祥, 周利龙, 冯又柏, 等. C2反应蛋白与冠状动脉病变的相关性及其临床意义[J ] . 心脏杂志,2002 ,14(6) :485 - 487.

备注/Memo

备注/Memo:
收稿日期：2004-2-18
更新日期/Last Update: 2004-09-01