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|本期目录/Table of Contents|

冠心病患者内皮功能与血清SOD、丙二醛含量相关(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第3期
页码:
320-322
栏目:
临床研究
出版日期:
2006-06-25

文章信息/Info

Title:
Relationship of vascular endothelial function and content of serum superoxide dismutase and malonyldiadehyde in patients with coronary heart disease
作者:
马建林; 王圣; 李新明;  苏哲坦; 李斌; 陈关良; 王卫; 林劲; 张敬文; 吴忠
海南省人民医院心内科，海南 海口 570311
Author(s):
MA Jian-lin;  WANG Sheng;  LI Xin-ming;  SU Zhe-tan;  LI Bin;  CHEN Guan-liang;  WANG Wei;  LIN Jin;  ZHANG Jing-wen;  WU Zhong
Department of Cardiovascular Disease, Hainan Provincial People's Hospital, Haikou，Hainan 570311, China
关键词:
冠状动脉疾病; 血管内皮功能; 一氧化氮; 丙二醛; 超氧化物歧化酶
Keywords:
coronary disease; vascular endothelial function; nitric oxide; malonyldiadehyde; superoxide dismutase
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨冠心病（CHD）患者血管内皮功能与氧化应激的相关性。方法 选择不稳定型心绞痛（UA）患者20例和稳定型心绞痛（SA）患者20例以及正常对照组20例，分别采用硝酸还原酶法、硫代巴比妥酸比色法及黄嘌呤氧化法检测一氧化氮（NO）、超氧化物歧化酶（SOD）、丙二醛（MDA）含量。结果 与正常对照组相比，CHD组血浆中NO、SOD水平显著下降（P<0.05或P<0.01），MDA水平显著升高（均P<0.01)。与SA患者比较，UA患者NO水平变化更加显著（P<0.05）。结论 CHD患者尤其是UA患者血管内皮功能减退，NO水平降低，与氧化应激增强有关。
Abstract:
AIM To study the relationship of vascular endothelial function and oxidative stress by detecting the serum content of nitric oxide (NO), malonyldiadehyde (MDA) and superoxide dismutase (SOD) in patients with coronary heart disease (CHD). METHODS The levels of serum NO, MDA and SOD in 20 patients with unstable angina pectoris (UA), 20 with stable angina pectoris (SA) and 20 normal cases were measured respectively by nitrate reductase, thiobarbituric acid and xanthine oxidase methods. RESULTS Compared with those in control group, the Levels of NO and SOD in CHD patients significantly decreased (P<0.01) but the levels of MDA significantly elevated (P<0.05). Compared with the patients with SA, the changes of NO were much more pronounced in patients with UA than those with SA (P<0.05). CONCLUSION The results suggest that the serum levels of NO and vascular endothelial decrease in patients with CHD, especially those with UA, which is related to the increased oxidative stress.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2005-02-06.作者简介：马建林, 主任医师,教授 Tel：（0898）68642121
更新日期/Last Update: