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普鲁布考对急性冠脉综合征患者血浆oxLDL、炎症因子的干预效应 (PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第4期
页码:
434-437
栏目:
临床研究
出版日期:
2007-08-01

文章信息/Info

Title:
Effects of Probucol in plasma oxLDL and hsCRP in patients with acute coronary syndrome
作者:
董红梅;  黄岚; 宋耀明; 晋军; 耿召华; 宋明宝; 武晓静; 于世勇
第三军医大学新桥医院全军心血管研究所，重庆 400037
Author(s):
DONG Hongmei;  HUANG Lan;  SONG Yaoming;  JIN Jun;  GENG Zhaohua;  SONG Mingbao;  WU Xiaojing;  YU Shiyong
Institute of Cardiology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
关键词:
冠状动脉疾病; 氧化低密度脂蛋白; 炎症介导素类
Keywords:
coronary syndrome;  oxidative low density lipoprotein;  inflammation mediators
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 观察普罗布考对急性冠脉综合征(ACS)患者血浆氧化低密度脂蛋白（oxLDL）、肿瘤坏死因子α(TNFα)及高敏C反应蛋白（hsCRP）干预效应。方法 ACS患者51例，随机分为两组，普罗布考组(P组)和常规治疗组(C组)，检测外周血oxLDL、TNFα、hsCRP,用药治疗3月，观察治疗前后指标变化。 结果 治疗后P组相对于C组oxLDL、TNFα及hsCRP浓度降低明显。P组治疗后血浆oxLDL水平与TNFα、hsCRP均为正相关。结论 普罗布考可降低oxLDL、TNFα及hsCRP，具有抗氧化、抗炎作用。
Abstract:
AIM To observe the effects of Probucol in plasma oxidative low density lipoprotein, tumornecrosis factorα and high sensitivity Creactive protein in patients with acute coronary syndrome (ACS). METHODS Fiftyone ACS patients were divided randomly into a Probucol treatment group (P) and a conventional treatment group (C). Oxidized lowdensity lipoprotein (oxLDL), tumornecrosis factorα (TNFα) and high sensitivity Creactive protein (hsCRP) were respectively measured in peripheral blood. These variables were analyzed after a 3month Probucol treatment. RESULTS The levels of oxLDL, TNFα and HsCRP were significantly higher in ACS patient. There was a significantly positive correlation between the level of oxLDL, TNFα, hsCRP and the degree of ACS. The levels of oxLDL and TNFα, hsCRP decreased significantly after a 3 month treatment and more significantly in the Probucol group than those in the conventional group. The linear correlation analysis showed that plasma oxLDL was positively correlated with hsCRP and TNFα after Probucol treatment in ACS patients. CONCLUSION oxLDL, TNFα and hsCRP increase remarkably in ACS patients and are correlated with the degree of CHD.

参考文献/References

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［12］朱冰坡，范利，李小鹰, 等. 普罗布考对老年下肢动脉硬化症患者内皮舒张功能的影响［J］. 中华老年心脑血管病杂志, 2005,7(1): 17-19.

备注/Memo

备注/Memo:
收稿日期：2006-06-23 基金项目：国家自然科学基金项目资助（No.30470729）通信作者：黄岚，教授，主任医师,主要从事血管内皮的损伤及修复与冠心病防治的研究Email：huanglans＠21cn.com 作者简介：董红梅，主治医师，硕士Email：hmdong＠126.com
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