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冠状动脉节段性痉挛和冠状动脉病变程度与血浆oxLDL水平相关(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第4期
页码:
438-440
栏目:
临床研究
出版日期:
2007-08-01

文章信息/Info

Title:
Plasma oxLDL is positively correlated with coronary artery segmental spasm and severity of coronary atherosclerosis
作者:
何喜民;  向定成;  何建新;  邱健;  马骏;  洪长江
广州军区广州总医院心血管内科, 广东 广州 51001
Author(s):
HE Ximin;  XIANG Dingcheng;  HE Jianxin;  QIU Jian;  MA Jun;  HONG Changjiang
Department of Cardiology, PLA Guangzhou General Hospital, Guangzhou Military Area Command, Guangzhou 510010, Guangdong, China
关键词:
冠状动脉痉挛; 心绞痛; 稳定型; 氧化性低密度脂蛋白; 动脉粥样硬化
Keywords:
coronary artery spasm; stable angina pectoris; oxidized lowdensity lipoprotien; atherosclerosis
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨血浆氧化型低密度脂蛋白（oxLDL）水平与冠状动脉痉挛(CAS组)及稳定型心绞痛(SAP组)患者冠状动脉病变程度之间的关系。方法 CAS组(n=31):临床上具有胸痛表现,冠状动脉造影无显著狭窄并经过乙酰胆碱试验确诊的患者；SAP组（n=35）:稳定的劳力型心绞痛患者；对照组(n=24),为健康体检者。3组于清晨空腹采取静脉血,采用ELISA法检测血浆oxLDL含量,按照痉挛与非痉挛、弥漫性痉挛和节段性痉挛以及SAP患者冠脉病变范围进行分组比较其oxLDL水平。结果 SAP组血浆oxLDL含量均高于对照组和CAS组（P<0.01），CAS组血浆oxLDL含量高于对照组,但无统计学意义；节段性痉挛患者血浆oxLDL水平较弥漫性痉挛患者高（P
Abstract:
AIM To determinate the level of plasma oxidized lowdensity lipoprotein (oxLDL) in patients with coronary artery spasm (CAS) and to explore the relationship between oxidized lowdensity lipoprotein and coronary spasm and lesion extent in coronary artery with stable angina pectoris (SAP). METHODS Plasma oxLDL was measured by enzymelinked immunosorbent assay in 90 patients who were divided into 3 groups: CAS group (n=31), those with chest pain but no significant coronary artery stenosis and diagnosed by acetylcholine test, SAP group (n=35), those with stable effort angina, and healthy control group (n=24). The plasma oxLDL was compared between the groups of spasm and nonspasm, segmental spasm and diffuse spasm, singlevessel lesion and multivessel lesion in SAP. RESULTS The level of plasma oxLDL was higher in patients with SAP than that in CAS patients, higher in patients with segmental spasm than that in those with diffuse spasm (P<0.05), and was remarkable higher in patients with multivessel lesion than those with singlevessel SAP or in patients with segmental spasm, respectively (P<0.01). CONCLUSION Plasma oxLDL is positively correlated with segmental CAS and the severity of coronary atherosclerosis.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2006-05-08.基金项目：广东省自然科学基金项目资助（No：032168）通讯作者：向定成，主任医师，主要从事冠心病介入诊断和治疗研究Email：dcxiang@yahoo.com.cn 作者简介：何喜民，硕士生Email:hebiyixing@163.com
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