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|本期目录/Table of Contents|

丹参多酚酸盐对UAP患者冠脉内支架置入术后血清IL-6、IL-8及TNF-α水平的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第5期
页码:
705-707,711
栏目:
临床研究
出版日期:
2010-06-22

文章信息/Info

Title:
Effect of salvianolate on IL-6, IL-8 and TNF-α level in patients with unstable angina pectoris after stent implantation
作者:
吴兴利; 李德印; 李金珉; 颜伟; 卢才义; 朱梅; 陈琪
解放军总医院老年心血管病研究所,北京 100853
Author(s):
WU Xing-li;  LI De-yin;  LI Jin-min;  YAN Wei;  LU Cai-yi;  ZHU Mei;  CHEN Qi
Institute of Geriatric Cardiology, PLA General Hospital, Beijing 100853, China
关键词:
不稳定型心绞痛; 支架置入术; 丹参多酚酸盐; 细胞因子
Keywords:
drug-eluting stent;  percutaneous coronary intervention;  three-vessel disease;  complete revascularization;  incomplete revascularization
分类号:
R541. 4
DOI:
-
文献标识码:
A
摘要:
目的: 研究丹参多酚酸盐(SVL)对不稳定型心绞痛（UAP)患者冠脉内支架置入后，血清IL-6、IL-8及TNF-α水平的影响。方法: 将68例UAP患者随机分为常规治疗组（n=35）及SVL治疗组(SVL组,n=33),观察支架置入前、支架置入后24 h及1周，血清IL-6、IL-8和TNF-α水平的变化, 并与18例正常人比较。结果: 治疗前，UAP患者血清IL-6、IL-8和TNF-α的水平较正常对照组（n=18）明显升高(均P<0.01)。常规治疗组支架置入后24 h较治疗前明显升高(P<0.05)；治疗后1周较治疗前明显降低(P<0.05)。SVL组支架置入术后24 h，IL-8 和TNF-α的水平较治疗前明显降低(P<0.05)；而IL-6的水平降低不明显；1周后3种细胞因子的水平均明显降低(P<0.01)，并且较常规治疗组支架置入后24 h和1周均明显下降(P<0.01)。结论: SVL可能通过调节IL-6、IL-8和TNF-α的表达，减轻冠脉局部的炎症级联反应，对UAP患者及支架置入后发挥较全面的心血管保护作用。
Abstract:
AIM：To investigate the serum level of IL-6, IL-8 and TNF-α and the effect of salvianolate in patients with unstable angina pectoris (UAP) after stent implantation. METHODS: Sixty-eight patients undergoing stent implantation were divided randomly into conventional therapy group and salvianolate group. The levels of IL-6, IL-8 and TNF-α were evaluated by ELISA before and 24 h and 1 week after stent implantation, and the levels of the above cytokins were compared with those in 18 normal controls. RESULTS: The levels of serum IL-6, IL-8 and TNF-α in patients with UAP were higher than those in the control group (P<0.01). The levels of serum IL-8 and TNF-α decreased 24 h after stent implantation in salvianolate group (P<0.05), while the values of all the three cytokins significantly increased in the conventional therapy group (P<0.05). The levels of the three cytokins decreased in both the conventional therapy group (P<0.05）and the salvianolate group (P<0.01) 1 w after stent implantation. CONCLUSIONS: Salvianolate may inhibit the inflammation in coronary artery by decreasing the secretion of IL-6, IL-8 and TNF-α, thus playing a protective role in patients with UAP after stent implantation.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2009-09-13.基金项目：总后“十一·五”重点课题项目资助（2007-hz-014） 作者简介：吴兴利,副主任医师Email：WXL301@yahoo.com
更新日期/Last Update: 2010-06-22