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血管紧张素转换酶2基因的多态性与冠状动脉粥样硬化性心脏病的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第6期
页码:
901-904,908
栏目:
临床研究
出版日期:
2010-08-23

文章信息/Info

Title:
Association of angiotensin-converting enzyme 2 gene polymorphism with coronary heart disease
作者:
张永; 包宗明; 吴士礼; 杜永胜
蚌埠医学院第一附属医院心内科，安徽 蚌埠 233004
Author(s):
ZHANG Yong;  BAO Zong-ming;  WU Shi-li;  DU Yong-sheng
Department of Cardiology, First Affiliated Hospital, Bengbu Medical College, Bengbu 233004, Anhui, China
关键词:
血管紧张素转换酶2; 基因多态性; 冠状动脉疾病
Keywords:
angiotensin-converting enzyme 2;  Gene;  Polymorphism;  coronary diseases
分类号:
R543.3
DOI:
-
文献标识码:
A
摘要:
目的: 探讨血管紧张素转换酶2(ACE2)基因的多态性与皖北汉族人冠状动脉粥样硬化性心脏病（冠心病，CHD）的关系。方法: 采用聚合酶链反应和限制性片段长度多态性(PCR-RFLP)的方法，检测120例CHD患者与109例对照人群（排除CHD患者及健康体检者）的ACE2基因，并进行组间对照研究ACE2基因的多态性与CHD的相关性。结果: 在男性CHD患者中，G等位基因的频率明显高于对照组（分别为77.6%、60.7%，P<0.05)；在女性CHD患者中，携带G等位基因的基因型GG型、AG型的分布频率略高于对照组（分别为43.2%、29.5%和32.1%、28.3%），差别无统计学意义。结论: ACE2基因的多态性与皖北男性汉族人群CHD的发病可能存在相关性，携带G等位基因的男性人群发生CHD的危险性相对较大。
Abstract:
AIM：To explore the relationship between gene G9570A polymorphisms of angiotensin-converting enzyme 2 (ACE2) and coronary heart diseases (CHD) among Han population in Northern Anhui Province. METHODS: A total number of 120 patients with CHD and 109 healthy controls were investigated by case-control study. The polymorphisms of ACE2 gene were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: The G allele frequency in male patients with CHD was significantly higher than that in control group (77.6% vs. 60.7%, P<0.05). The GG and AG genotypes in female patients with CHD were slightly higher than those in control group (43.2% vs. 29.5% and 32.1% vs. 28.3% respectively), but no significant difference was found in the frequency of GG and AG genotypes between the female patients and the controls (χ2=0.634, P=0.427; χ2=1.875, P=0.173 respectively). CONCLUSION: The ACE2 gene polymorphism may be associated with coronary heart diseases among male Han population in northern Anhui Province. The male population carrying the G allele runs a higher risk of coronary heart diseases than those carrying other alleles.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2009-07-29.通讯作者：包宗明，主任医师，主要从事心血管疾病的研究Email:chinaBZM@126.com 作者简介：张永，硕士生Email:wudian6666@sina.com
更新日期/Last Update: 2010-08-22